大花翠雀花中的C-二萜生物碱。

C-Diterpenoid alkaloids from Delphinium anthriscifolium var. majus.

作者信息

Shan Lian-Hai, Zhang Ji-Fa, Gao Feng, Huang Shuai, Zhou Xian-Li

机构信息

a School of Life Science and Engineering, Southwest Jiaotong University , Chengdu 610031 , China.

b Key Laboratory of Advanced Technology of Materials , Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University , Chengdu 610031 , China.

出版信息

J Asian Nat Prod Res. 2018 May;20(5):423-430. doi: 10.1080/10286020.2017.1335309. Epub 2017 Jun 1.

DOI:10.1080/10286020.2017.1335309

PMID:28569094

Abstract

Five new C-diterpenoid alkaloids, anthriscifoltines C-G (1-5), along with four known diterpenoid alkaloids anthriscifolcines C-F (6-9), were isolated from the extract of Delphinium anthriscifolium var. majus. Their structures were elucidated by extensive spectroscopic analyses (including 1D-, 2D-NMR, and HR-ESI-MS). Compounds 1-5 were also evaluated for their cytotoxic activity against MCF-7, HepG2, and H460 human cancer cell lines.

摘要

从大花翠雀花的提取物中分离出5种新的C-二萜生物碱，即茴芹叶碱C-G（1-5），以及4种已知的二萜生物碱茴芹叶碱C-F（6-9）。通过广泛的光谱分析（包括一维、二维核磁共振和高分辨电喷雾电离质谱）阐明了它们的结构。还评估了化合物1-5对MCF-7、HepG2和H460人癌细胞系的细胞毒性活性。