研究了亚硝酸叔丁酯（TBN）作为氮原子源与2-乙烯基苯胺合成取代噌啉的反应及相关机理。
tert-Butyl nitrite (TBN) as the N atom source for the synthesis of substituted cinnolines with 2-vinylanilines and a relevant mechanism was studied.
作者信息
Pang XiaoBo, Zhao LianBiao, Zhou DaGang, He Ping Yong, An ZhenYu, Ni Ji Xiang, Yan RuLong
机构信息
State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Department of Chemistry, Lanzhou University, Lanzhou, Gansu, China.
出版信息
Org Biomol Chem. 2017 Aug 2;15(30):6318-6322. doi: 10.1039/c7ob01553d.
A green method to synthesize cinnolines by 6π electrocyclic reaction with alkenyl amines and TBN has been developed. TBN plays a dual role both as a nitrogen atom source and an oxidant in this procedure. Relevant mechanism experiments reveal that the reaction proceeds through electrocyclic reaction and with diazo hydroxide as a key intermediate.
已开发出一种通过烯基胺与TBN进行6π电环化反应合成噌啉的绿色方法。在此过程中，TBN既作为氮原子源又作为氧化剂发挥双重作用。相关机理实验表明，该反应通过电环化反应进行，且以重氮氢氧化物作为关键中间体。
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