聚乙二醇修饰脂质体的加工结构关系。
Processing-structure relationships of poly(ethylene glycol)-modified liposomes.
机构信息
Materials Science and Engineering Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
出版信息
Soft Matter. 2017 Aug 9;13(31):5228-5232. doi: 10.1039/c7sm00960g.
Abstract
Liposomes with PEG-modified surfaces are amenable to nanocarrier applications and can be prepared via two PEGylated lipid incorporation routes: before and after extrusion (i.e., co-extrusion and post-insertion, respectively). The current study quantifies the processing influence on PEG chain partitioning between the interior and exterior liposome surfaces for the first time using small angle neutron scattering.
摘要
具有聚乙二醇（PEG）修饰表面的脂质体适用于纳米载体应用，可以通过两种聚乙二醇化脂质掺入途径制备：在挤出之前和挤出之后（即共挤出和插入后）。本研究首次使用小角中子散射定量研究了处理对聚乙二醇链在脂质体内外表面之间分配的影响。
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2
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3
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Macromol Rapid Commun. 2015 Dec;36(23):2031-41. doi: 10.1002/marc.201500344. Epub 2015 Oct 12.
4
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5
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