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一种层层组装的 MoS 薄膜，作为用于小分子的激光解吸/电离质谱分析的高效平台。

A layer-by-layer assembled MoS thin film as an efficient platform for laser desorption/ionization mass spectrometry analysis of small molecules.

机构信息

Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.

出版信息

Nanoscale. 2017 Aug 3;9(30):10854-10860. doi: 10.1039/c7nr02949g.

DOI:10.1039/c7nr02949g
PMID:28730210
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5572770/
Abstract

A chip-based platform for laser desorption/ionization mass spectrometry (LDI-MS) analysis of small molecules was developed by utilizing layer-by-layer (LBL) assembly of MoS nanoflakes and polyallylamine on an arbitrary substrate. The LDI-MS efficiency of small molecules on MoS films increased as a function of LBL assembly cycles until reaching a saturation point. The optimized MoS nanoflake film exhibits high LDI-MS efficiency, salt tolerance, reusability and uniform ionic signal distribution, and its performance was further enhanced by surface modification with perfluoroalkanes mimicking a clathrate nanostructure.

摘要

基于层层自组装（LBL）技术，在任意基底上利用 MoS 纳米片和聚烯丙胺成功制备了用于激光解吸/电离质谱（LDI-MS）分析小分子的芯片平台。随着 LBL 组装循环次数的增加，小分子在 MoS 薄膜上的 LDI-MS 效率逐渐提高，直至达到饱和点。优化后的 MoS 纳米片薄膜具有较高的 LDI-MS 效率、耐盐性、可重复使用性和均匀的离子信号分布，其性能通过表面修饰进一步增强，修饰材料模拟了笼型纳米结构的全氟烷烃。

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本文引用的文献

[1]
Multifunctional Nanosystem for Synergistic Tumor Therapy Delivered by Two-Dimensional MoS.

ACS Appl Mater Interfaces. 2017-4-13

[2]
High Antibacterial Activity of Functionalized Chemically Exfoliated MoS.

ACS Appl Mater Interfaces. 2016-11-8

[3]
"RaMassays": Synergistic Enhancement of Plasmon-Free Raman Scattering and Mass Spectrometry for Multimodal Analysis of Small Molecules.

Sci Rep. 2016-10-4

[4]
MoS2/Ag nanohybrid: A novel matrix with synergistic effect for small molecule drugs analysis by negative-ion matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

Anal Chim Acta. 2016-9-21

[5]
Sensitivity Enhancement of Transition Metal Dichalcogenides/Silicon Nanostructure-based Surface Plasmon Resonance Biosensor.

Sci Rep. 2016-6-16

[6]
Chemical Dissolution Pathways of MoS2 Nanosheets in Biological and Environmental Media.

Environ Sci Technol. 2016-7-5

[7]
Functionalization of Two-Dimensional MoS2 : On the Reaction Between MoS2 and Organic Thiols.

Angew Chem Int Ed Engl. 2016-4-1

[8]
A direct assay of carboxyl-containing small molecules by SALDI-MS on a AgNP/rGO-based nanoporous hybrid film.

Analyst. 2016-4-25

[9]
Inkjet-printed gold nanoparticle surfaces for the detection of low molecular weight biomolecules by laser desorption/ionization mass spectrometry.

J Am Soc Mass Spectrom. 2015-11

[10]
Metabolomics in pharmaceutical research and development.

Curr Opin Biotechnol. 2015-12

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