Guimaraes A, Hauw J J, Escourolle R
Acta Neuropathol. 1979 Apr 12;46(1-2):133-7. doi: 10.1007/BF00684814.
An electron microscope study and quantitation of myelinated and unmyelinated fibers of seven nerve biopsies performed in sporadic cases of idiopathic sensory neuropathy is reported. The number of myelinated fibers is markedly decreased or absent in every case. On the contrary, the unmyelinated fiber numbers are normal or increased. In most cases, the small diameter myelinated and unmyelinated fibers proportions are higher than those of control biopsies. The electron microscope study discloses evidence of degeneration of Wallerian tye and regeneration is also indicated by quantitative studies. Regenerative phenomena seen more obvious in sporadic cases than in previously reported studies of familial cases.
报告了对散发性特发性感觉神经病病例进行的7次神经活检中髓鞘化和无髓鞘化纤维的电子显微镜研究及定量分析。在每个病例中,髓鞘化纤维的数量显著减少或缺失。相反,无髓鞘化纤维的数量正常或增加。在大多数病例中,小直径髓鞘化和无髓鞘化纤维的比例高于对照活检。电子显微镜研究揭示了华勒氏型变性的证据,定量研究也表明存在再生现象。散发性病例中观察到的再生现象比先前报道的家族性病例研究中更为明显。