手性高价碘(III)引发的酮的不对称α-磺酰基-和 α-磷酰基-氧化反应。
Asymmetric α-Sulfonyl- and α-Phosphoryl-Oxylation of Ketones by a Chiral Hypervalent Iodine(III).
机构信息
Institut de Chimie des Substances Naturelles , CNRS UPR 2301, Université Paris-Sud, Université Paris-Saclay, 1, av. de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
Université de Strasbourg , CNRS, LCM UMR 7509, 67000 Strasbourg, France.
出版信息
J Org Chem. 2017 Nov 17;82(22):11877-11883. doi: 10.1021/acs.joc.7b01597. Epub 2017 Jul 31.
PMID:28731345
Abstract
An enantioselective direct oxygenation of propiophenone derivatives mediated by a catalytic or stoichiometric amount of new chiral non-C2-symmetric iodoarenes(III) is reported. The reaction gives an easy entry to optically active α-sulfonyl- and α-phosphoryl oxyketones in respectable yields and enantioselectivities.
摘要
报告了一种新型手性非 C2 对称碘代芳烃（III）催化或化学计量量介导的丙酰苯衍生物的对映选择性直接氧化反应。该反应以可观的产率和对映选择性提供了易于获得的光学活性 α-磺酰基和 α-膦酰基氧基酮。
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