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移植专业人员对活体肾捐赠资格标准不断变化的模式的态度。

Attitudes among transplant professionals regarding shifting paradigms in eligibility criteria for live kidney donation.

作者信息

Lafranca Jeffrey A, Spoon Emerentia Q W, van de Wetering Jacqueline, IJzermans Jan N M, Dor Frank J M F

机构信息

Department of Surgery, division of HPB and Transplant Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Department of Internal Medicine, division of Nephrology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

出版信息

PLoS One. 2017 Jul 21;12(7):e0181846. doi: 10.1371/journal.pone.0181846. eCollection 2017.

Abstract

BACKGROUND

The transplant community increasingly accepts extended criteria live kidney donors, however, great (geographical) differences are present in policies regarding the acceptance of these donors, and guidelines do not offer clarity. The aim of this survey was to reveal these differences and to get an insight in both centre policies as well as personal beliefs of transplant professionals.

METHODS

An online survey was sent to 1128 ESOT-members. Questions were included about several extended donor criteria; overweight/obesity, older age, vascular multiplicity, minors as donors and comorbidities; hypertension, impaired fasting glucose, kidney stones, malignancies and renal cysts. Comparisons were made between transplant centres of three regions in Europe and between Europe and other countries worldwide.

RESULTS

331 questionnaires were completed by professionals from 55 countries. Significant differences exist between regions in Europe in acceptance of donors with several extended criteria. Median refusal rate for potential live donors is 15%. Furthermore, differences are seen regarding pre-operative work-up, both in specialists who perform screening as in preoperative imaging.

CONCLUSIONS

Remarkably, 23.4% of transplant professionals sometimes deviate from their centre policy, resulting in more or less comparable personal beliefs regarding extended criteria. Variety is seen, proving the need for a standardized approach in selection, preferably evidence based.

摘要

背景

移植界越来越多地接受扩大标准的活体肾供体,然而,在接受这些供体的政策方面存在很大的(地理)差异,并且指南并未提供明确指导。本次调查的目的是揭示这些差异,并深入了解移植专业人员的中心政策以及个人信念。

方法

向1128名欧洲器官移植学会(ESOT)成员发送了在线调查问卷。问题包括几个扩大的供体标准;超重/肥胖、年龄较大、血管多样性、未成年人作为供体以及合并症;高血压、空腹血糖受损、肾结石、恶性肿瘤和肾囊肿。对欧洲三个地区的移植中心之间以及欧洲与世界其他国家之间进行了比较。

结果

来自55个国家的专业人员完成了331份问卷。欧洲不同地区在接受具有多种扩大标准的供体方面存在显著差异。潜在活体供体的中位拒绝率为15%。此外,在进行筛查的专科医生以及术前影像学检查方面,术前检查也存在差异。

结论

值得注意的是,23.4%的移植专业人员有时会偏离其中心政策,导致在扩大标准方面或多或少具有相似的个人信念。存在差异,这证明在选择时需要一种标准化方法(最好是基于证据的方法)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/360c/5521829/be0cff748d58/pone.0181846.g001.jpg

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