新疆汉族和维吾尔族2型糖尿病患者血清骨钙素与糖脂代谢的关系：两项横断面研究
Association between serum osteocalcin and glucose/lipid metabolism in Chinese Han and Uygur populations with type 2 diabetes mellitus in Xinjiang: two cross-sectional studies.
作者信息
Chen Yuan, Zhao Qiang, Du Guoli, Xu Yancheng
机构信息
Department of Endocrinology, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, Hubei, 430071, China.
Department of Endocrinology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China.
出版信息
Lipids Health Dis. 2017 Jul 21;16(1):139. doi: 10.1186/s12944-017-0512-8.
BACKGROUND
Recent studies have shown osteocalcin (OC) plays an important role in regulating glucose and lipid metabolism. Thus, the aim of this study was to investigate the association of OC with glucose and lipid metabolism in patients with type 2 diabetes mellitus (T2DM) in the Chinese Han and Uygur population.
METHODS
A total of 1397 T2DM patients (705 Han and 692 Uygur T2DM patients) were enrolled in the present study. Lipid profile, glucose metabolic indices and total OC (TOC) were measured. Homeostasis model assessment of β-cells function (HOMA-β), insulin sensitivity (HOMA-IS) and insulin resistance (HOMA-IR) were also calculated in all participants. Pearson/Spearman correlation analysis and multivariate stepwise regression analysis were adopted to test the relationships between OC and those parameters.
RESULTS
Uygur T2DM patients had significantly higher body mass index (BMI), hemoglobin A1C (HbA1C) and lower TOC compared with their Han counterparts (all P < 0.05). HbA1C was negatively associated with TOC in all Uygur and Han T2DM patients (Total: Uygur: t = -3.468, P = 0.001; Han: t = -4.169, P < 0.001). BMI was inversely associated with TOC in all Uygur T2DM patients (Males: t = -2.893, P = 0.014; Females: t = -2.250, P = 0.027, respectively). Multivariate stepwise regression analysis showed that TOC was positively correlated with HOMA-β in the Uygur male group (β = 2.101, P = 0.040) and negatively associated with BMI in all Uygur T2DM patients (Males: β = -1.563, P = 0.011; Females: β = -1.284, P = 0.016, respectively). No significant differences were observed between TOC and lipid profiles in all participants (all P > 0.05).
CONCLUSION
There were differences in the associations between TOC and glucose metabolism in Han and Uygur T2DM patients, indicating genetic factors may play a role in modulating OC and glucose metabolism in different ethnic population.
背景
近期研究表明骨钙素（OC）在调节糖脂代谢中起重要作用。因此，本研究旨在探讨中国汉族和维吾尔族2型糖尿病（T2DM）患者中OC与糖脂代谢的关系。
方法
本研究共纳入1397例T2DM患者（705例汉族和692例维吾尔族T2DM患者）。检测血脂谱、糖代谢指标和总OC（TOC）。所有参与者还计算了β细胞功能的稳态模型评估（HOMA-β）、胰岛素敏感性（HOMA-IS）和胰岛素抵抗（HOMA-IR）。采用Pearson/Spearman相关分析和多元逐步回归分析来检验OC与这些参数之间的关系。
结果
与汉族T2DM患者相比，维吾尔族T2DM患者的体重指数（BMI）、糖化血红蛋白（HbA1C）显著更高，而TOC更低（所有P<0.05）。在所有维吾尔族和汉族T2DM患者中，HbA1C与TOC呈负相关（总体：维吾尔族：t=-3.468，P=0.001；汉族：t=-4.169，P<0.001）。在所有维吾尔族T2DM患者中，BMI与TOC呈负相关（男性：t=-2.893，P=0.014；女性：t=-2.250，P=0.027）。多元逐步回归分析显示，在维吾尔族男性组中TOC与HOMA-β呈正相关（β=2.101，P=0.040），在所有维吾尔族T2DM患者中TOC与BMI呈负相关（男性：β=-1.563，P=0.011；女性：β=-1.284，P=0.016）。所有参与者的TOC与血脂谱之间未观察到显著差异（所有P>0.05）。
结论
汉族和维吾尔族T2DM患者中TOC与糖代谢的关联存在差异，表明遗传因素可能在不同种族人群中调节OC和糖代谢方面发挥作用。
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