在中国新疆，血糖正常的汉族、维吾尔族和哈萨克族男性之间的血脂谱、胰岛素敏感性和胰岛素抵抗存在差异。

Different lipid profiles, insulin sensitivity, and insulin resistance among Han, Uygur, and Kazak men with normal glucose tolerance in Xinjiang, China.

机构信息

Endocrinology Department of Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, Xinjiang, 830001, China.

School of Medicine, Shihezi University, Shihezi, Xinjiang, 832000, China.

出版信息

Lipids Health Dis. 2018 Sep 7;17(1):209. doi: 10.1186/s12944-018-0863-9.

DOI:10.1186/s12944-018-0863-9

PMID:30193578

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6128984/

Abstract

BACKGROUND

This study aimed to determine the differences in clinical parameters among Han, Uygur, and Kazak men with normal glucose tolerance.

METHODS

Participants' data from the China National Diabetes and Metabolic Disorders Study pertaining to Han, Uygur, and Kazak men from the Xinjiang province were used (n = 930). Pearson's correlation was used to examine the relationship between HOMA-IR, Matsuda Index, and clinical characteristics.

RESULTS

HOMA-IR of Han men was significantly higher than in Uygurs and Kazaks (P < 0.001). The Matsuda Index of Kazaks was significantly higher than that of Hans and Uygurs (P < 0.001). While Kazaks had the highest BMI, WC, SBP, and DBP; they also had the highest HDL-C and lowest TG (P < 0.001). TG of Uygurs was significantly higher than that of Hans and Kazaks (P < 0.001). In Hans and Kazaks, the TG/HDL-C ratio increased with HOMA-IR quartiles; there was no association in Uygurs. In Hans and Kazaks, the TG/HDL-C ratio decreased with Matsuda index quartiles; there was no association in Uygurs. Multivariate linear regression showed that HOMA-IR was independently associated with ethnicity, BMI and TG/HDL-C ratio (P < 0.01), while Matsuda index was independently associated with ethnicity, BMI, LDL-C levels (P < 0.001) and TG/HDL-C ratio (P < 0.001).

CONCLUSIONS

In conclusion, Han, Uygur, and Kazak men had different lipid profiles, BMI, and WC. Han men had the highest insulin resistance while Kazak men had the highest insulin sensitivity.

摘要

背景

本研究旨在比较汉族、维吾尔族和哈萨克族男性人群中血糖正常者的临床参数差异。

方法

使用中国糖尿病和代谢紊乱研究中来自新疆的汉族、维吾尔族和哈萨克族男性参与者的数据（n=930）。采用 Pearson 相关性分析来研究 HOMA-IR、Matsuda 指数与临床特征之间的关系。

结果

汉族男性的 HOMA-IR 明显高于维吾尔族和哈萨克族（P<0.001）。哈萨克族的 Matsuda 指数明显高于汉族和维吾尔族（P<0.001）。虽然哈萨克族的 BMI、WC、SBP 和 DBP 最高，但他们的 HDL-C 最高，TG 最低（P<0.001）。维吾尔族的 TG 明显高于汉族和哈萨克族（P<0.001）。在汉族和哈萨克族中，随着 HOMA-IR 四分位数的增加，TG/HDL-C 比值升高；而在维吾尔族中则没有相关性。在汉族和哈萨克族中，随着 Matsuda 指数四分位数的增加，TG/HDL-C 比值降低；而在维吾尔族中则没有相关性。多元线性回归显示，HOMA-IR 与种族、BMI 和 TG/HDL-C 比值独立相关（P<0.01），而 Matsuda 指数与种族、BMI、LDL-C 水平（P<0.001）和 TG/HDL-C 比值（P<0.001）独立相关。