Hadziselimović F, Thommen L, Girard J, Herzog B
J Urol. 1986 Jul;136(1 Pt 2):274-6. doi: 10.1016/s0022-5347(17)44839-7.
Testicular biopsies from 29 infants with cryptorchidism between birth (gestational age as early as 36 weeks) and 9 months of age were compared to 34 biopsies from the testes of boys at postmortem examination, or during operation for a hydrocele or hernia. The total number of germ cells was similar in both groups but normal testes showed a transformation of gonocytes into spermatogonia to an extent that was not seen in the cryptorchid testes. Cryptorchid testes also showed markedly reduced numbers of Leydig cells compared to normal. These postnatal changes occurred in the normal testes at the same time that the increase is seen in luteinizing and follicle-stimulating hormones during the first few months of life and they are believed to be a consequence of this hormonal activity. It is postulated that the postnatal surge of gonadotropins may be responsible for priming the testes for subsequent development and fertility.
对29例出生时（胎龄早至36周）至9个月大的隐睾症婴儿的睾丸活检组织，与34例男孩死后尸检或因鞘膜积液或疝气手术时所取睾丸的活检组织进行了比较。两组的生殖细胞总数相似，但正常睾丸中生殖母细胞向精原细胞的转化程度在隐睾睾丸中未见。与正常睾丸相比，隐睾睾丸中的间质细胞数量也明显减少。这些出生后的变化在正常睾丸中出现的同时，在生命的最初几个月促黄体生成素和促卵泡生成素也出现增加，并且它们被认为是这种激素活性的结果。据推测，促性腺激素出生后的激增可能是为睾丸随后的发育和生育能力做好准备的原因。
