Departamento de Química Orgánica, Laboratorio de Investigación "Ignacio Ribas", Universidade de Santiago de Compostela, E-15782, Santiago de Compostela, Spain.
Departamento de Química, Facultade de Ciencias-CICA, Universidade da Coruña, E-15071, A Coruña, Spain.
J Steroid Biochem Mol Biol. 2018 Mar;177:247-249. doi: 10.1016/j.jsbmb.2017.07.016. Epub 2017 Jul 18.
A convergent approach to 25S,26-dihydroxyvitamin D (1) has been developed in our laboratories. The A-ring and the CD-fragment are constructed from ergocalciferol and Inhoffen-Lythgoe diol, respectively. The triene system is assembled by a Wittig-Horner coupling. With this convergent synthesis, a novel hydroxylated vitamin D metabolite in our laboratory is available for biological testing.
我们实验室开发了一种 25S、26-二羟维生素 D（1）的汇聚方法。A 环和 CD 片段分别由麦角钙化醇和 Inhoffen-Lythgoe 二醇构建。三烯系统通过 Wittig-Horner 偶联组装。通过这种汇聚合成，我们实验室中一种新型的羟基化维生素 D 代谢物可用于生物学测试。
