用于有效乳液配方的水性壳聚糖和 B 型明胶溶液的表面行为和体相性质。

Surface behavior and bulk properties of aqueous chitosan and type-B gelatin solutions for effective emulsion formulation.

机构信息

University Lille Nord de France, F-5900 Lille, France; ENSAIT, GMTEX, F-59100, Roubaix, France; Department of Applied Science and Technology, Politecnico di Torino, Italy; College of Textile and Clothing Engineering, Soochow University, Suzhou, Jiangsu, 215123, China.

University Lille Nord de France, F-5900 Lille, France; ENSAIT, GMTEX, F-59100, Roubaix, France.

出版信息

Carbohydr Polym. 2017 Oct 1;173:202-214. doi: 10.1016/j.carbpol.2017.06.001. Epub 2017 Jun 3.

DOI:10.1016/j.carbpol.2017.06.001

PMID:28732859

Abstract

The behavior of aqueous chitosan (CH), type-B gelatin (GB) and CH-GB coacervate was studied on oil-in-water emulsion formulation at various pH and concentration ratio. The coacervate was formed by phase separation at ratios CH:GB, 1:10 to 1:1 with total biopolymer concentrations of 0.55%-1.0% (w/v) at pH 4.0-5.5. Soluble complexes were formed below pH 5.0 and coacervate formation was confirmed at pH 5.0 and above by zeta potential and UV-spectroscopy measurements. The coacervate formation was found maximum at the CH-GB ratios of 1:10 and 1:5 at pH 5.5. Formulated emulsions (>10μm droplets) using 1% (w/v) chitosan and GB were found stable (+52.5mv and creaming index 86%) and unstable respectively. Emulsion stabilized by mixed CH:GB 1:5 (3%w/v) had no creaming effect. The instability was attributed to the lower surface activity (K=5.0Lg) of pure GB compared to CH (K=14.3Lg). The formulation and methods can successfully tune the stability of the emulsions.

摘要

研究了不同 pH 值和浓度比下，壳聚糖（CH）、B 型明胶（GB）及其共凝聚物在水包油乳液制剂中的行为。共凝聚物是在 pH 值为 4.0-5.5 时，通过相分离在 CH:GB 比例为 1:10 至 1:1 形成的，总生物聚合物浓度为 0.55%-1.0%（w/v）。低于 pH 5.0 时形成可溶性复合物，在 pH 5.0 及以上时通过动电位和紫外光谱测量证实共凝聚物的形成。在 pH 5.5 时，共凝聚物的形成在 CH:GB 比例为 1:10 和 1:5 时达到最大值。使用 1%（w/v）壳聚糖和 GB 配制的乳液（>10μm 液滴）分别发现稳定（+52.5mv 和 86%的积层指数）和不稳定。由混合 CH:GB 1:5（3%w/v）稳定的乳液没有积层作用。不稳定性归因于与 CH（K=14.3Lg）相比，纯 GB 的表面活性（K=5.0Lg）较低。该配方和方法可以成功调节乳液的稳定性。