幽门弯曲菌、尿素酶、氢离子逆向弥散与胃溃疡

Campylobacter pyloridis, urease, hydrogen ion back diffusion, and gastric ulcers.

作者信息

Hazell S L, Lee A

出版信息

Lancet. 1986 Jul 5;2(8497):15-7. doi: 10.1016/s0140-6736(86)92561-4.

Abstract

Campylobacter pyloridis, a bacterium implicated as the aetiological agent of gastritis and possibly gastric ulcers, has a very high urease activity. The rapid hydrolysis of urea at intercellular junctions results in alterations in the milieu of the gastric epithelium preventing the normal passage of hydrogen ions (H+) from the gastric glands through the mucus to the lumen and permits back diffusion. A consequence of H+ back diffusion is hypochlorhydria and a predisposition to ulcer formation. Several conflicting reports on the physiology of normal, gastritis, and ulcerated stomachs are reconciled by this hypothesis.

摘要

幽门弯曲杆菌是一种被认为是胃炎及可能的胃溃疡病因的细菌，其具有非常高的脲酶活性。尿素在细胞间连接处的快速水解导致胃上皮细胞环境发生改变，阻止氢离子（H⁺）从胃腺正常通过黏液进入管腔，并允许其逆向扩散。H⁺逆向扩散的一个后果是胃酸过少以及易形成溃疡。这一假说调和了关于正常胃、胃炎胃和溃疡胃生理学的几份相互矛盾的报告。