极早早产儿早期全肠内营养后的生长及发病率
Growth and morbidity of extremely preterm infants after early full enteral nutrition.
作者信息
Maas Christoph, Franz Axel R, von Krogh Stefanie, Arand Jörg, Poets Christian F
机构信息
Department of Neonatology, University Children's Hospital, Eberhard-Karls University, Tübingen, Germany.
Center for Pediatric Clinical Studies, University Children's Hospital, Eberhard-Karls University, Tübingen, Germany.
出版信息
Arch Dis Child Fetal Neonatal Ed. 2018 Jan;103(1):F79-F81. doi: 10.1136/archdischild-2017-312917. Epub 2017 Jul 21.
OBJECTIVES
To evaluate feasibility and consequences of accelerated feeding advancement on short-term outcomes in extremely low gestational age neonates (ELGANs) who stayed in our institution for >28 days.
METHODS
Retrospective single-centre cohort analysis covering the years 2011-2013. Data are presented as median (IQR).
RESULTS
Infants '(n=77) birth weight was 745 (640 to 960) g and gestational age at birth 26.7 (25.1 to 27.4) weeks. Full enteral feeds were attained by postnatal day 7 (5 to 11). Weight gain from birth to discharge was 14.3 (13.3 to 16.1) g/kg/day, change in SD score for weight -0.03 (-0.55 to 0.46) and 0.09 (-0.78 and 0.82) for head circumference. Rates of necrotising enterocolitis and spontaneous intestinal perforation in all ELGANs admitted during the study period were 3.1% and 9.4%, respectively.
CONCLUSIONS
This cohort of ELGANs showed good weight gain and head growth after early full enteral nutrition. The impact of this feeding practice on neonatal morbidity and long-term outcome remains to be tested in adequately powered randomised trials.
目的
评估在我院住院超过28天的极早产儿（ELGANs）中加速喂养进程对短期结局的可行性及影响。
方法
对2011年至2013年进行回顾性单中心队列分析。数据以中位数（四分位间距）表示。
结果
婴儿（n = 77）出生体重为745（640至960）g，出生胎龄为26.7（25.1至27.4）周。出生后第7天（5至11天）实现完全经口喂养。从出生到出院体重增加为14.3（13.3至16.1）g/kg/天，体重标准差评分变化为-0.03（-0.55至0.46），头围标准差评分变化为0.09（-0.78至0.82）。研究期间所有入院的ELGANs中坏死性小肠结肠炎和自发性肠穿孔发生率分别为3.1%和9.4%。
结论
这组ELGANs在早期完全肠内营养后体重增加良好且头部生长良好。这种喂养方式对新生儿发病率和长期结局的影响仍有待在足够样本量的随机试验中进行验证。
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