Marsubrin Putri Maharani Tristanita, Aryadevi Ni Nyoman Berlian, Medise Bernie Endyarni, Devaera Yoga
Department of Child Health Faculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Department of Child Health Universitas Indonesia Hospital, Depok, Indonesia.
Int J Pediatr. 2024 Sep 16;2024:8880297. doi: 10.1155/2024/8880297. eCollection 2024.
: Effective oral feeding is one of the critical milestones that must be achieved by preterm infants. While gestational age and birth weight have been recognized as influential factors, recent studies have found additional variables impacting the achievement of full oral feeding (FOF). This study is aimed at describing factors associated with the attainment of FOF in preterm infants. : This retrospective cohort study examines preterm infants born between 28 and 34 weeks' gestation admitted to Dr. Cipto Mangunkusumo General Hospital in Jakarta between July and December 2016. Comparative analysis utilized the Kruskal-Wallis test, while Cox's regression was employed for multivariate analysis to assess factors influencing the achievement of FOF. : This study included 87 preterm infants meeting the inclusion criteria. The median gestational age was 33 weeks (IQR: 3). The most common birth weight range was 1500-1999 g (51.7%). Median durations from birth to the first feed, full enteral feed, and FOF were observed to be 1 day (IQR: 1), 6 days (IQR: 10), and 14 days (IQR: 24), respectively. Notably, the duration of oxygen therapy, episodes of sepsis, and frequency of blood transfusions showed significant associations with the time taken to achieve FOF. : This study found significant associations between the time to achieve FOF and factors such as oxygen therapy duration, sepsis episodes, and frequency of blood transfusion. These findings highlight the importance of considering these factors in managing preterm infants. However, a further prospective study is warranted to identify additional factors that influence feeding milestones in preterm infants.
有效的经口喂养是早产儿必须达到的关键里程碑之一。虽然胎龄和出生体重已被认为是影响因素,但最近的研究发现了其他影响完全经口喂养(FOF)实现的变量。本研究旨在描述与早产儿实现FOF相关的因素。
这项回顾性队列研究考察了2016年7月至12月间在雅加达的Cipto Mangunkusumo综合医院收治的胎龄在28至34周之间的早产儿。比较分析采用Kruskal-Wallis检验,而Cox回归用于多变量分析,以评估影响FOF实现的因素。
本研究纳入了87名符合纳入标准的早产儿。中位胎龄为33周(四分位间距:3)。最常见的出生体重范围是1500 - 1999克(51.7%)。从出生到首次喂养、完全肠内喂养和FOF的中位持续时间分别观察到为1天(四分位间距:1)、6天(四分位间距:10)和14天(四分位间距:24)。值得注意的是,氧疗持续时间、败血症发作次数和输血频率与实现FOF所需的时间显示出显著关联。
本研究发现实现FOF的时间与氧疗持续时间、败血症发作次数和输血频率等因素之间存在显著关联。这些发现凸显了在管理早产儿时考虑这些因素的重要性。然而,有必要进行进一步的前瞻性研究,以确定影响早产儿喂养里程碑的其他因素。