Jiang Youjing, He Wang, Wang Hui, Chen Dan, Bai Xiaogang, Li Jienan, Liang Weibo, Zhang Lin
Department of Forensic Genetics, West China School of Basic Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041, China.
Department of Forensic Medicine, Sichuan Police College, Luzhou, Sichuan, 646000, China.
Int J Legal Med. 2018 Jan;132(1):145-147. doi: 10.1007/s00414-017-1639-x. Epub 2017 Jul 21.
A 21-plex DIP (deletion and insertion polymorphism) panel has a good performance in analyzing biogeographic ancestry in three main global population groups (European, African, and Asian). This panel was used to investigate 450 unrelated individuals in seven Chinese ethnic groups (Han, Dong, Miao, Zhuang, Uyghur, Tibetan, and Mongolian). Allele frequencies were calculated. Mho (mean value of observed heterozygosity) ranged from 0.3019 to 0.4367, MHe (mean value of expected heterozygosity) ranged from 0.31175 to 0.38341, CMP (combined matching probability) ranged from 3.5834E-07 to 2.5985E-06, CDP (combined power of discrimination) ranged from 0.99999740150 to 0.99999964166, and CPE (combined power of paternity exclusion) ranged from 0.85884504 to 0.97949131. The results suggested the potential of the panel for individual identification and paternity testing in Chinese populations. Pairwise genetic differences Fst values (-0.00091 to 0.05873) and the analysis by STRUCTURE indicated that Chinese populations have good internal consistency.
一个21重的缺失和插入多态性（DIP）面板在分析全球三个主要人群组（欧洲、非洲和亚洲）的生物地理血统方面表现良好。该面板用于调查七个中国民族（汉族、侗族、苗族、壮族、维吾尔族、藏族和蒙古族）的450名无关个体。计算了等位基因频率。观察到的杂合度均值（Mho）范围为0.3019至0.4367，预期杂合度均值（MHe）范围为0.31175至0.38341，联合匹配概率（CMP）范围为3.5834E - 07至2.5985E - 06，联合鉴别力（CDP）范围为0.99999740150至0.99999964166，联合亲权排除力（CPE）范围为0.85884504至0.97949131。结果表明该面板在中国人群个体识别和亲权检测方面具有潜力。成对遗传差异Fst值（-0.00091至0.05873）以及STRUCTURE分析表明中国人群具有良好的内部一致性。
