Gudowska Monika, Cylwik Bogdan, Chrostek Lech
Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok, Poland.
Department of Pediatric Laboratory Diagnostics, Medical University of Bialystok, Bialystok, Poland.
Acta Biochim Pol. 2017;64(3):451-457. doi: 10.18388/abp.2016_1443. Epub 2017 Jul 19.
The common pathway leading to liver fibrosis and cirrhosis is growing deposition of extracellular matrix (ECM). It results from molecular and histological rearrangement of collagens, glycoproteins and hyaluronans. Hyaluronic acid is a chief component of the extracellular matrix of connective tissues and plays the main structural role in the formation of ECM. The most important organ involved in the synthesis of hyaluronic acid is the liver. In this paper the meaning of hyaluronic acid in the diagnostics of liver diseases is discussed. Here, we focus on the described changes of hyaluronic acid concentration in the pathological processes of the liver, including alcoholic and non-alcoholic liver diseases. The results of published clinical studies have shown its high diagnostic sensitivity, which probably enables its application in laboratory diagnosis.
导致肝纤维化和肝硬化的共同途径是细胞外基质（ECM）沉积不断增加。这是由胶原蛋白、糖蛋白和透明质酸的分子及组织学重排引起的。透明质酸是结缔组织细胞外基质的主要成分，在细胞外基质形成中起主要结构作用。参与透明质酸合成的最重要器官是肝脏。本文讨论了透明质酸在肝脏疾病诊断中的意义。在此，我们重点关注所描述的肝脏病理过程中透明质酸浓度的变化，包括酒精性和非酒精性肝病。已发表的临床研究结果显示其具有较高的诊断敏感性，这可能使其能够应用于实验室诊断。
