Department of Psychiatry, Beth Israel Deaconess Medical Center, 75 Fenwood Rd, Boston, MA 02115, USA.
Department of Psychiatry, Beth Israel Deaconess Medical Center, 75 Fenwood Rd, Boston, MA 02115, USA; Department of Psychiatry, Harvard Medical School, 75 Fenwood Rd, Boston, MA 02115, USA.
Psychiatry Res Neuroimaging. 2017 Sep 30;267:36-44. doi: 10.1016/j.pscychresns.2017.07.002. Epub 2017 Jul 14.
Abnormalities in the subcortical brain regions that support cognitive functions have been reported in schizophrenia. Relatives of those with schizophrenia often present with psychosis-like traits (schizotypy) and similar cognition as those with schizophrenia. To evaluate the relationships between subcortical structure, schizotypy, and cognitive function, we assessed shape and volume of the hippocampus, amygdala and thalamus in untreated youth at familial high risk for schizophrenia (HRSZ). The sample consisted of 66 HRSZ and 69 age-matched healthy controls (HC). Subjects' cognitive functions and schizotypy were assessed, and T1-weighted brain MRI were analyzed using the FSL software FIRST. The right hippocampus and right amygdala showed significantly increased concavity (inward displacement) in HRSZ compared to HC. While regional subcortical shape displacements were significantly correlated with sustained attention and executive function scores in HC, fewer correlations were seen in HRSZ. This suggests a possible alteration of the local structure-function relationship in subcortical brain regions of HRSZ for these cognitive domains, which could be related to anomalous plasticity.
已有研究报道，精神分裂症患者的皮质下脑区存在异常。精神分裂症患者的亲属常表现出类似精神病的特征（精神分裂症特质）和与精神分裂症患者相似的认知功能。为了评估皮质下结构、精神分裂症特质和认知功能之间的关系，我们评估了未经治疗的精神分裂症高危家族青年（HRSZ）的海马体、杏仁核和丘脑的形状和体积。该样本包括 66 名 HRSZ 和 69 名年龄匹配的健康对照组（HC）。对受试者的认知功能和精神分裂症特质进行了评估，并使用 FSL 软件 FIRST 分析了 T1 加权脑 MRI。与 HC 相比，HRSZ 的右侧海马体和右侧杏仁核显示出明显的凹度（向内位移）增加。虽然局部皮质下形状位移与 HC 的持续注意力和执行功能评分显著相关，但在 HRSZ 中相关性较少。这表明，对于这些认知领域，HRSZ 的皮质下脑区的局部结构-功能关系可能发生了改变，这可能与异常的可塑性有关。
