寨卡病毒感染

Zika Virus Infection.

作者信息

Shirley Debbie-Ann T, Nataro James P

机构信息

Department of Pediatrics, University of Virginia School of Medicine, Box 800386, Charlottesville, VA 22908-0386, USA.

出版信息

Pediatr Clin North Am. 2017 Aug;64(4):937-951. doi: 10.1016/j.pcl.2017.03.012.

DOI:10.1016/j.pcl.2017.03.012

PMID:28734519

Abstract

In less than 2 years since entry into the Americas, we have witnessed the emergent spread of Zika virus into large subsets of immunologically naïve human populations and then encountered the devastating effects of microcephaly and brain anomalies that can arise from in utero infection with the virus. Diagnostic evaluation and management of affected infants continues to evolve as our understanding of Zika virus rapidly advances. The development of a safe and effective vaccine holds the potential to attenuate the spread of infection and limit the impact of congenital infection.

摘要

自进入美洲不到两年的时间里，我们目睹了寨卡病毒在大量免疫未成熟人群中迅速传播，随后又遭遇了子宫内感染该病毒可能引发的小头畸形和脑部异常等毁灭性后果。随着我们对寨卡病毒的了解迅速加深，对受影响婴儿的诊断评估和治疗也在不断发展。研发一种安全有效的疫苗有望减缓感染传播，并限制先天性感染的影响。