Song Xiaoyu, Liu Bo, Cui Lingyu, Zhou Biao, Liu Weiwei, Xu Fanxing, Hayashi Toshihiko, Hattori Shunji, Ushiki-Kaku Yuko, Tashiro Shin-Ichi, Ikejima Takashi
China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang 110016, China; Medical Research Center, Shenzhen University Health Science Center, Shenzhen 518060, China.
China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang 110016, China.
Physiol Behav. 2017 Oct 1;179:487-493. doi: 10.1016/j.physbeh.2017.07.023. Epub 2017 Jul 19.
Depression is one of the most frequent psychiatric disorders of Alzheimer's disease (AD). Depression and anxiety are associated with increased risk of developing AD. Silibinin, a flavonoid derived from milk thistle (Silybum marianum), has been used as a hepato-protectant in the clinical treatment of liver diseases. In this study, the effect of silibinin on Aβ-induced anxiety/depression-like behaviors in rats was investigated. Silibinin significantly attenuated anxiety/depression-like behaviors caused by Aβ1-42-treatment as shown in tail suspension test (TST), elevated plus maze (EPM) and forced swimming tests (FST). Moreover, silibinin was able to attenuate the neuronal damage in the hippocampus of Aβ1-42-injected rats. Silibinin-treatment up-regulated the function through BDNF/TrkB pathway and attenuated autophagy in the hippocampus. Our study provides a new insight into the protective effects of silibinin in the treatment of anxiety/depression.
抑郁症是阿尔茨海默病（AD）最常见的精神障碍之一。抑郁和焦虑与患AD的风险增加有关。水飞蓟宾是一种从水飞蓟（Silybum marianum）中提取的黄酮类化合物，在肝脏疾病的临床治疗中被用作肝脏保护剂。在本研究中，研究了水飞蓟宾对Aβ诱导的大鼠焦虑/抑郁样行为的影响。如尾悬挂试验（TST）、高架十字迷宫试验（EPM）和强迫游泳试验（FST）所示，水飞蓟宾显著减轻了由Aβ1-42处理引起的焦虑/抑郁样行为。此外，水飞蓟宾能够减轻注射Aβ1-42的大鼠海马体中的神经元损伤。水飞蓟宾处理通过BDNF/TrkB途径上调功能并减轻海马体中的自噬。我们的研究为水飞蓟宾在治疗焦虑/抑郁方面的保护作用提供了新的见解。
