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慢性硬膜下血肿手术后复发和并发症的预测因素:一项基于人群的研究。

Predictors of Recurrence and Complications After Chronic Subdural Hematoma Surgery: A Population-Based Study.

作者信息

Bartek Jiri, Sjåvik Kristin, Kristiansson Helena, Ståhl Fredrik, Fornebo Ida, Förander Petter, Jakola Asgeir S

机构信息

Department of Clinical Neuroscience, Section for Neurosurgery, Karolinska Institutet and Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden; Department of Neurosurgery, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Department of Neurosurgery, University Hospital of North Norway, Tromsø, Norway.

出版信息

World Neurosurg. 2017 Oct;106:609-614. doi: 10.1016/j.wneu.2017.07.044. Epub 2017 Jul 19.

Abstract

OBJECTIVE

To investigate predictors of recurrence and moderate to severe complications after burr-hole surgery for chronic subdural hematoma (cSDH).

METHODS

A retrospective review was conducted in a Scandinavian single-center population-based cohort of 759 adult patients with cSDH operated with burr-hole surgery between January 1, 2005 and December 31, 2010. Possible predictors of recurrence and complications, assessed using a standardized reporting system of adverse events, were identified and analyzed in univariable analyses. Variables with a P value < 0.10 were included in a multivariable regression model.

RESULTS

Recurrence was observed in 85 patients (11.2%), whereas moderate to severe complications were observed in 35 patients (4.6%). Bilateral hematoma (odds ratio [OR], 2.05; 95% confidence interval [CI], 1.25-3.35; P < 0.01) and largest hematoma diameter in millimeters (OR, 1.05; 95% CI, 1.01-1.09; P < 0.01) were independent predictors of recurrence in the multivariable model analysis. Glasgow Coma Scale (GCS) score of <13 (OR, 6.06; 95% CI, 2.72-13.51; P < 0.01) and Charlson Comorbidity Index (CCI) >1 (OR, 2.28; 95% CI, 1.10-4.75; P = 0.03) were independent predictors of moderate to severe complications.

CONCLUSIONS

Recurrence after cSDH surgery is more often encountered in patients with radiologically more extensive disease reflected by bilateral hematoma and large hematoma diameter. On the other hand, moderate to severe complications are more often seen in patients in a worse clinical condition, reflected by decreased level of consciousness and more comorbidities.

摘要

目的

探讨慢性硬膜下血肿(cSDH)钻孔手术后复发及中重度并发症的预测因素。

方法

对2005年1月1日至2010年12月31日期间在斯堪的纳维亚单中心基于人群队列中接受钻孔手术的759例成年cSDH患者进行回顾性研究。使用不良事件标准化报告系统评估复发和并发症的可能预测因素,并在单变量分析中进行识别和分析。P值<0.10的变量纳入多变量回归模型。

结果

85例患者(11.2%)出现复发,35例患者(4.6%)出现中重度并发症。双侧血肿(比值比[OR],2.05;95%置信区间[CI],1.25 - 3.35;P < 0.01)和血肿最大直径(毫米)(OR,1.05;95% CI,1.01 - 1.09;P < 0.01)是多变量模型分析中复发的独立预测因素。格拉斯哥昏迷量表(GCS)评分<13(OR,6.06;95% CI,2.72 - 13.51;P < 0.01)和Charlson合并症指数(CCI)>1(OR,2.28;95% CI,1.10 - 4.75;P = 0.03)是中重度并发症的独立预测因素。

结论

cSDH手术后复发在影像学表现为双侧血肿和血肿直径较大的疾病范围更广的患者中更常见。另一方面,中重度并发症在临床状况较差的患者中更常见,表现为意识水平下降和合并症更多。

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