Gershon S
Neuropsychobiology. 1986;15 Suppl 1:22-7. doi: 10.1159/000118275.
Chronic pain is refractory to most currently marketed regimens. Part of the problem in achieving satisfactory results in treatment is understanding the mechanism that causes chronic pain. One hypothesis currently being investigated explores the role of serotonin. As such, products that block the reuptake of serotonin, such as trazodone and amitriptyline, are being studied. The rationale for the current hypothesis, including psychopharmacology and the role of serotonin reuptake blockers, will be reviewed.
慢性疼痛对目前市场上的大多数治疗方案都具有耐药性。在治疗中难以取得满意效果的部分原因在于对慢性疼痛产生机制的理解。目前正在研究的一种假说探讨了血清素的作用。因此，正在对诸如曲唑酮和阿米替林等能阻断血清素再摄取的药物进行研究。本文将对当前这一假说的基本原理，包括精神药理学及血清素再摄取阻滞剂的作用进行综述。
