Imura K, Kamata S, Hata S, Okada A, Watanabe T, Wada H
Pharmacol Biochem Behav. 1986 May;24(5):1323-8. doi: 10.1016/0091-3057(86)90191-7.
To elucidate disturbances of brain amine metabolism in hepatic coma, the effects of dietary histidine and methionine loading on the brain levels of amino acids and transmitter amines and on behavior were examined in rats with a portacaval shunt (PCS rats). Surgical construction of a portacaval shunt exaggerated the increase in brain histamine caused by dietary histidine loading 4 weeks after operation. Although the marked increase in the brain level of methionine itself did not affect on the brain levels of catecholamines, serotonin, and histamine, brain level of 5-HIAA was decreased in PCS rats on methionine-enriched diet. Diminished spontaneous activity was observed in PCS rats on either diet, which could not be related to the disturbance of brain amine metabolism caused by excess histidine and methionine. These results indicated that histamine was involved in the derangement of brain amine metabolism in PCS rats, and that direct effect of dietary methionine loading on the brain levels of transmitter amines was not observed in PCS rats. The etiological relation of these substances to hepatic coma should be further investigated.
为阐明肝昏迷时脑胺代谢紊乱的情况，研究了膳食组氨酸和蛋氨酸负荷对门腔分流大鼠（PCS大鼠）脑氨基酸和递质胺水平以及行为的影响。门腔分流手术造成的分流在术后4周时加剧了膳食组氨酸负荷引起的脑组胺增加。尽管蛋氨酸本身在脑中的显著增加并未影响儿茶酚胺、5-羟色胺和组胺的脑水平，但在富含蛋氨酸的饮食喂养下，PCS大鼠脑内5-羟吲哚乙酸水平降低。无论哪种饮食喂养，PCS大鼠的自发活动均减少，这与过量组氨酸和蛋氨酸引起的脑胺代谢紊乱无关。这些结果表明，组胺参与了PCS大鼠脑胺代谢紊乱，且未观察到膳食蛋氨酸负荷对PCS大鼠脑内递质胺水平的直接影响。这些物质与肝昏迷的病因学关系有待进一步研究。
