Yamada K, Matsuo N, Matsuda T, Tanaka M, Furukawa T, Koja T, Fukuda T
Pharmacol Biochem Behav. 1986 May;24(5):1445-9. doi: 10.1016/0091-3057(86)90208-x.
Oral administration of isofloxythepin (0.5-8.0 mg/kg) inhibited decapitation convulsions in a dose-dependent manner as shown by decreasing the incidence and shortening the convulsion's duration, the effects continuing until 24 hr after administration. Zotepine (8, 16 mg/kg, SC) also decreased the duration but not the incidence of the convulsion. However, the other neuroleptics such as haloperidol, spiperone, perphenazine, trifluoperazine, pimozide and sulpiride failed to affect decapitation convulsions. Reserpine (8 mg/kg, SC) inhibited decapitation convulsions, accompanied by decreasing levels of norepinephrine, dopamine and serotonin in the spinal cord. Isofloxythepin at doses of 4 and 8 mg/kg, PO which completely abolished decapitation convulsions, failed to change norepinephrine and dopamine levels but increased serotonin levels in the spinal cord. Isofloxythepin (0.5-8.0 mg/kg) increased serum prolactin levels in a dose-dependent manner and zotepine (16 mg/kg), haloperidol (1 mg/kg) and reserpine (8 mg/kg) also elevated the levels. The results imply that both isofloxythepin and zotepine, but not the other neuroleptics, inhibit convulsions without decreasing spinal levels of norepinephrine which appears to be the amine most directly involved in the occurrence of decapitation convulsions, although these neuroleptics enhance prolactin secretion by blocking dopamine receptors in the pituitary.
口服异氟西汀（0.5 - 8.0毫克/千克）以剂量依赖的方式抑制断头惊厥，表现为惊厥发生率降低和惊厥持续时间缩短，这些作用持续至给药后24小时。佐替平（8、16毫克/千克，皮下注射）也缩短了惊厥持续时间，但未降低惊厥发生率。然而，其他抗精神病药物如氟哌啶醇、螺哌隆、奋乃静、三氟拉嗪、匹莫齐特和舒必利对断头惊厥没有影响。利血平（8毫克/千克，皮下注射）抑制断头惊厥，同时脊髓中去甲肾上腺素、多巴胺和5-羟色胺水平降低。口服剂量为4和8毫克/千克的异氟西汀可完全消除断头惊厥，虽未改变脊髓中去甲肾上腺素和多巴胺水平，但可提高5-羟色胺水平。异氟西汀（0.5 - 8.0毫克/千克）以剂量依赖的方式提高血清催乳素水平，佐替平（16毫克/千克）、氟哌啶醇（1毫克/千克）和利血平（8毫克/千克）也可提高该水平。结果表明，异氟西汀和佐替平而非其他抗精神病药物可抑制惊厥，且不降低脊髓中去甲肾上腺素水平，去甲肾上腺素似乎是最直接参与断头惊厥发生的胺类物质，尽管这些抗精神病药物通过阻断垂体中的多巴胺受体来增强催乳素分泌。
