Leppanen Jenni, Cardi Valentina, Paloyelis Yannis, Simmons Andy, Tchanturia Kate, Treasure Janet
King's College London, The Institute of Psychiatry, Psychology, and Neuroscience, Department of Psychological Medicine, United Kingdom.
King's College London, The Institute of Psychiatry, Psychology, and Neuroscience, Department of Psychological Medicine, United Kingdom.
Biol Psychol. 2017 Sep;128:105-111. doi: 10.1016/j.biopsycho.2017.07.010. Epub 2017 Jul 20.
People with anorexia nervosa (AN) have difficulties in a wide range of social-emotional processes. Previous work suggests atypical involvement of the prefrontal cortex (PFC), amygdala, insula, and fusiform gyri during social-emotional processing in AN.
Twenty women with AN and twenty healthy comparison (HC) women were presented with happy, fearful, and neutral faces during a functional magnetic resonance imaging study. Group differences were investigated in the following regions of interest: lateral PFC, amygdala, insula, and fusiform gyri.
The HC participants showed significantly increased recruitment of the ventrolateral PFC and amygdala in the fearful > neutral contrast relative to the AN participants. The AN participants showed a significantly increased recruitment of a small cluster in the right posterior insula in the happy > neutral contrast.
These findings are in line with the hypothesis that people with AN have a blunted response to negative and atypical exaggerated response to positive emotionally provoking stimuli.
神经性厌食症（AN）患者在广泛的社会情感过程中存在困难。先前的研究表明，在AN患者进行社会情感加工时，前额叶皮层（PFC）、杏仁核、脑岛和梭状回存在异常参与。
在一项功能磁共振成像研究中，向20名患有AN的女性和20名健康对照（HC）女性展示快乐、恐惧和中性的面孔。在以下感兴趣区域研究组间差异：外侧PFC、杏仁核、脑岛和梭状回。
与AN参与者相比，HC参与者在恐惧>中性对比中腹外侧PFC和杏仁核的激活显著增加。AN参与者在快乐>中性对比中右侧后脑岛的一个小簇激活显著增加。
这些发现与以下假设一致，即AN患者对负面刺激反应迟钝，对正面情绪激发刺激反应异常夸张。
