全球体能状态评分：评估肾移植患者身体机能的新工具。

Global Performance Status Score: A New Tool to Assess Physical Performance in Kidney Transplant Patients.

作者信息

Esposito P, Furini F, Gregorini M, Pattonieri E F, Corradetti V, La Porta E, Caramella E, Calatroni M, Petrucci L, Klersy C, Rampino T

机构信息

Unit of Nephrology, Dialysis and Transplantation, Fondazione IRCCS Policlinico San Matteo, and University of Pavia, Pavia, Italy.

Rehabilitation Unit, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.

出版信息

Transplant Proc. 2017 Jul-Aug;49(6):1270-1275. doi: 10.1016/j.transproceed.2017.02.052.

DOI:10.1016/j.transproceed.2017.02.052

PMID:28735992

Abstract

BACKGROUND

Information on physical performance in renal transplantation is limited because of the shortage of specifically designed evaluation instruments. Therefore, we elaborated and validated the Global Performance Status (GloPerSta) score to provide a new and comprehensive tool, exploring the different components of physical performance in kidney transplant patients.

METHODS

We elaborated the GloPerSta score on the basis of the data obtained from a cross-sectional study, in which we evaluated the physical performance of a cohort of kidney transplant patients. The results of these analyses were weighted to describe the different contribution of any single test, via the generation of a structural equation model, resulting in the definition of the GloPerSta. Then, to internally validate this score, we studied its correlation with clinical parameters and quality of life (evaluated as KDQOL-SF, Kidney Disease Quality of Life-Short Form) in the same patient population.

RESULTS

We enrolled 132 patients in whom the functional tests revealed a great heterogeneity. GloPerSta allowed the stratification of the patients in 3 different physical performance categories (low: score 0-11; medium: 12-22; high: 23-33). Internal validation showed that GloPerSta was directly and significantly correlated with the quality of life and allograft function, independent of the time from transplantation.

CONCLUSIONS

The GloPerSta is a reliable tool to assess physical performance in a kidney transplant population. Its application might be of help in identifying patients needing intensive and personalized rehabilitation programs.

摘要

背景

由于缺乏专门设计的评估工具，肾移植患者身体机能方面的信息有限。因此，我们制定并验证了全球身体机能状态（GloPerSta）评分，以提供一种全新且全面的工具，探究肾移植患者身体机能的不同组成部分。

方法

我们基于一项横断面研究的数据制定了GloPerSta评分，在该研究中我们评估了一组肾移植患者的身体机能。通过生成结构方程模型对这些分析结果进行加权，以描述任何单项测试的不同贡献，从而确定了GloPerSta。然后，为了对该评分进行内部验证，我们在同一患者群体中研究了它与临床参数及生活质量（以KDQOL-SF，即肾脏病生活质量简表进行评估）的相关性。