Servicio de Oncología Médica, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, España.
Servicio de Oncología Médica, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, España.
Med Clin (Barc). 2017 Oct 23;149(8):345-350. doi: 10.1016/j.medcli.2017.06.010. Epub 2017 Jul 21.
There are several tumours associated with gastrointestinal stromal tumour (GIST), most of them without an apparent family relationship; only 5% of them occur within the context of a family syndrome. In this article the corresponding literature about the former has been reviewed. A search in Pubmed was carried out, the methodology of which is described in detail in the body of the article. A total of 88 articles have been chosen for the review, next to the application of limits as well as a manual review. GIST patients have a twofold risk of developing a second tumour than the general population (4-33% of them develop a second neoplasm, either synchronic or metachronic). Most incident tumours associated with GIST are gastrointestinal and genitourinary tumours. In addition, patients with second tumours have a worse survival rate than those without second tumours.
存在几种与胃肠道间质瘤（GIST）相关的肿瘤，其中大多数与家族关系不明显；只有 5%的肿瘤发生在家族综合征的背景下。本文综述了前者的相关文献。在 Pubmed 中进行了搜索，文章主体详细描述了该方法。共选择了 88 篇文章进行综述，除了应用限制外，还进行了手动审查。与普通人群相比，GIST 患者发生第二肿瘤的风险增加了两倍（4-33%的患者会出现同步或异时性第二肿瘤）。与 GIST 相关的大多数偶发肿瘤是胃肠道和泌尿生殖道肿瘤。此外，患有第二肿瘤的患者比没有第二肿瘤的患者生存率更差。
