原核 Argonaute 蛋白：新型基因组编辑工具？
Prokaryotic Argonaute proteins: novel genome-editing tools?
机构信息
Laboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University, Stippeneng 4, 6708WE Wageningen, The Netherlands.
Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
出版信息
Nat Rev Microbiol. 2018 Jan;16(1):5-11. doi: 10.1038/nrmicro.2017.73. Epub 2017 Jul 24.
Argonaute proteins constitute a highly diverse family of nucleic acid-guided proteins. They were first discovered in eukaryotes as key proteins in RNA interference systems, but homologous prokaryotic Argonaute proteins (pAgos) have also been found in archaea and bacteria. In this Progress article, we focus on long pAgo variants, a class of pAgos that are involved in nucleic acid-guided host defence against invading nucleic acids, and discuss the potential of pAgos in genome editing.
Argonaute 蛋白构成了一个高度多样化的核酸引导蛋白家族。它们最初在真核生物中被发现是 RNA 干扰系统的关键蛋白，但在古菌和细菌中也发现了同源的原核 Argonaute 蛋白 (pAgos)。在这篇进展文章中，我们重点介绍长 pAgo 变体，这一类 pAgos 参与了核酸引导的宿主防御入侵核酸，并讨论了 pAgos 在基因组编辑中的潜力。
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