Alvarado-de la Barrera Claudia, Reyes-Terán Gustavo
Departamento de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City.
Pathog Immun. 2017;2(1):126-137. doi: 10.20411/pai.v2i1.195. Epub 2017 May 2.
As a consequence of late presentation for HIV care, a significant proportion of individuals develop immune reconstitution inflammatory syndrome (IRIS) soon after initiation of antiretroviral therapy. Incidence, predictors, and models of pathogenesis of IRIS vary in the literature. Here we discuss factors that may contribute to this lack of consensus. We propose that different pathogens drive different types of IRIS and suggest that these clinical conditions should be studied individually and not grouped under the general heading of "IRIS."
由于就诊接受HIV治疗较晚,相当一部分人在开始抗逆转录病毒治疗后不久就会发生免疫重建炎症综合征(IRIS)。IRIS的发病率、预测因素和发病机制模型在文献中各不相同。在此我们讨论可能导致这种缺乏共识的因素。我们提出不同的病原体引发不同类型的IRIS,并建议这些临床情况应单独研究,而不应归类于“IRIS”这一统称之下。