Zhuang Zhu-Lun, Jin Yu, Yan Kun-Long, Cheng Wei-Xia
Children's Hospital of Nanjing Medical University, Nanjing, 210008, China.
Arch Virol. 2017 Nov;162(11):3511-3515. doi: 10.1007/s00705-017-3494-y. Epub 2017 Jul 24.
Human caliciviruses (HuCVs) have been recognized as a major cause of sporadic viral diarrhea in children, among which norovirus genotype GII.4 is the most prevalent genotype. Stool and saliva samples were collected from 295 children with acute diarrhea and 150 asymptomatic children at a hospital in China. The HuCV detection rate was 10.85% (32/295) among the children with acute diarrhea, and all of these 32 children were either HBGA secretors (12/32) or partial secretors (20/32). HuCV was detected in two (1.33%) of the 150 samples obtained from the asymptomatic children. Of the norovirus-GII.3-positive children, 60% had blood type O, but only 17.29% of the symptomatic patients had blood type O, indicating that type O individuals could be at higher risk of GII.3 infection. However, due to the limited number of individuals in this study, further studies with a larger number of subjects should be conducted to verify this hypothesis.
人杯状病毒（HuCVs）已被确认为儿童散发性病毒性腹泻的主要病因，其中诺如病毒GII.4基因型是最常见的基因型。在中国一家医院，从295名急性腹泻儿童和150名无症状儿童中采集了粪便和唾液样本。急性腹泻儿童中HuCV检出率为10.85%（32/295），这32名儿童均为HBGA分泌者（12/32）或部分分泌者（20/32）。从无症状儿童获得的150份样本中有两份（1.33%）检测到HuCV。在诺如病毒GII.3阳性儿童中，60%为O型血，但有症状患者中只有17.29%为O型血，这表明O型血个体可能感染GII.3的风险更高。然而，由于本研究中的个体数量有限，应开展更多受试者的进一步研究以验证这一假设。
