Okita H, Block M
Am J Clin Pathol. 1979 Jun;71(6):645-50. doi: 10.1093/ajcp/71.6.645.
The development of a rapid rate of regeneration of osteomalacic bone in a patient treated for acute granulocytic leukemia has been demonstrated for the first time. This positive bone balance was most intense at the time of maximal depletion of leukemic tissue. The authors postulate that new formation of osteomalcic bone is due to inability to maintain the rate of calcification parallel to that of bone formation. A similar abnormality occurs in egg-laying birds, in rapidly growing children on a diet suboptimal in vitamin D who have rickets, and in some patients with osteoblastic metastases.
首次证明了一名接受急性粒细胞白血病治疗的患者中骨软化骨快速再生率的发展情况。这种正性骨平衡在白血病组织最大程度消耗时最为强烈。作者推测，骨软化骨的新形成是由于无法维持与骨形成平行的钙化速率。类似的异常情况发生在产蛋鸟类、维生素D摄入不足且患有佝偻病的快速生长儿童以及一些患有成骨性转移的患者中。
