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Cisplatin Binding Sites in Human H-Chain Ferritin.

作者信息

Ferraro Giarita, Ciambellotti Silvia, Messori Luigi, Merlino Antonello

机构信息

Department of Chemical Sciences, University of Naples Federico II , Complesso Universitario di Monte Sant'Angelo, Via Cintia, I-80126 Naples, Italy.

Dipartimento di Chimica, Università di Firenze , Via Della Lastruccia 3, Sesto Fiorentino, 50019 Firenze, Italy.

出版信息

Inorg Chem. 2017 Aug 7;56(15):9064-9070. doi: 10.1021/acs.inorgchem.7b01072. Epub 2017 Jul 24.

DOI:10.1021/acs.inorgchem.7b01072
PMID:28737381
Abstract

The aim of this work is to identify the cisplatin binding sites on human H-chain ferritin. High-resolution X-ray crystallography reveals that cisplatin binds four distinct protein sites, that is, the side chains of His136 and Lys68, the side chain of His105, the side chain of Cys90 and the side chain of Cys102. These Pt binding sites are compared with those observed for the adduct that cisplatin forms upon encapsulation within horse spleen L-chain ferritin (87% identity with human L-chain ferritin).

摘要

相似文献

[1]
Cisplatin Binding Sites in Human H-Chain Ferritin.

Inorg Chem. 2017-8-7

[2]
High-resolution X-ray structures of human apoferritin H-chain mutants correlated with their activity and metal-binding sites.

J Mol Biol. 2007-1-12

[3]
Metal binding sites of human H-chain ferritin and iron transport mechanism to the ferroxidase sites: a molecular dynamics simulation study.

Proteins. 2013-4-1

[4]
Cisplatin binding to human serum albumin: a structural study.

Chem Commun (Camb). 2015-6-11

[5]
Incorporation of organometallic Ru complexes into apo-ferritin cage.

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[6]
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J Inorg Biochem. 2012-3-9

[7]
The crystal structure analysis of the relative binding of cisplatin and carboplatin in a mixture with histidine in a protein studied at 100 and 300 K with repeated X-ray irradiation.

Acta Crystallogr D Biol Crystallogr. 2013-1

[8]
Cisplatin-Protein Interactions: Unexpected Drug Binding to N-Terminal Amine and Lysine Side Chains.

Inorg Chem. 2016-8-15

[9]
Structural investigation of the complexation properties between horse spleen apoferritin and metalloporphyrins.

Proteins. 1996-3

[10]
Loading of iron into recombinant rat liver ferritin heteropolymers by ceruloplasmin.

Arch Biochem Biophys. 1997-5-15

引用本文的文献

[1]
Bioactive Molecules Delivery through Ferritin Nanoparticles: Sum Up of Current Loading Methods.

Molecules. 2024-8-27

[2]
Determination of unbound platinum concentrations in human plasma using ultrafiltration and precipitation methods.

J Pharmacol Toxicol Methods. 2024

[3]
Encapsulation of copper phenanthroline within horse spleen apoferritin: characterisation, cytotoxic activity and ability to retain temozolomide.

RSC Adv. 2024-4-29

[4]
A new and efficient procedure to load bioactive molecules within the human heavy-chain ferritin nanocage.

Front Mol Biosci. 2023-1-13

[5]
Evaluation of Auranofin Loading within Ferritin Nanocages.

Int J Mol Sci. 2022-11-16

[6]
Apoferritin-Encapsulated Jerantinine A for Transferrin Receptor Targeting and Enhanced Selectivity in Breast Cancer Therapy.

ACS Omega. 2022-6-13

[7]
UVC inactivation of pathogenic samples suitable for cryo-EM analysis.

Commun Biol. 2022-1-11

[8]
Development of purification process for dual-function recombinant human heavy-chain ferritin by the investigation of genetic modification impact on conformation.

Eng Life Sci. 2021-6-19

[9]
Time-Resolved Studies of Ytterbium Distribution at Interfacial Surfaces of Ferritin-like Dps Protein Demonstrate Metal Uptake and Storage Pathways.

Biomedicines. 2021-7-29

[10]
Direct fluorogenic detection of palladium and platinum organometallic complexes with proteins and nucleic acids in polyacrylamide gels.

Sci Rep. 2020-7-23

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