Ferraro Giarita, Massai Lara, Messori Luigi, Merlino Antonello
Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte Sant'Angelo, Via Cintia, I-80126, Napoli, Italy.
Chem Commun (Camb). 2015 Jun 11;51(46):9436-9. doi: 10.1039/c5cc01751c.
The reaction between cisplatin and human serum albumin (HSA) was investigated by X-ray crystallography and crystal structures of the cisplatin/HSA adduct were eventually solved for the first time. Structural data unambiguously prove that cisplatin mainly binds to His105 and Met329 side chains; additional binding sites are detected at His288, Met298, and Met548 and at His535, His67 and His247.
通过X射线晶体学研究了顺铂与人血清白蛋白（HSA）之间的反应，并首次最终解析出了顺铂/HSA加合物的晶体结构。结构数据明确证明顺铂主要与His105和Met329侧链结合；在His288、Met298和Met548以及His535、His67和His247处检测到了其他结合位点。
