[2015年云南省德宏州HIV-1耐药传播阈值调查]

[HIV-1 drug resistance transmission threshold survey in Dehong prefecture of Yunnan province, 2015].

作者信息

Chen M, Wang J B, Xing H, Ma Y L, Yang J, Chen H C, Yao S T, Luo H B, Duan X, Wang Y K, Duan S, Jia M H

机构信息

Institute for AIDS/STDs Control and Prevention, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China.

Department of AIDS/STDs Control and Prevention, Dehong Prefecture Center for Disease Control and Prevention, Mangshi 678400, China.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2017 Jul 10;38(7):959-962. doi: 10.3760/cma.j.issn.0254-6450.2017.07.022.

DOI:10.3760/cma.j.issn.0254-6450.2017.07.022

PMID:28738474

Abstract

To study the HIV-1 drug resistance transmission level in HIV infected persons receiving no antiviral therapy in Dehong prefecture of Yunnan province in 2015. A total of 72 plasma samples were collected from recently reported HIV-infected persons aged 16-25 years in Dehong from January to July 2015 for drug resistance gene detection. Forty eight samples were successfully sequenced and analyzed. Among them, 31.2 (15/48) were from Chinese, and 68.8 (33/48) were from Burmese. Based on sequences, HIV genotypes included URF (52.08, 25/48), CRF01_AE (16.67, 8/48), RF07_BC (10.42, 5/48), subtype B (6.25, 3/48), subtype C (6.25, 3/48), CRF57_BC (6.25, 3/48) and CRF08_BC (2.08, 1/48). One drug resistant mutation site to non-nucleoside analog reverse transcriptase inhibitor (NNRTI) and two drug resistant mutation site to nucleoside analog reverse transcriptase inhibitor (NRTI) were detected in four sequences. Based on the statistical method of HIV drug resistance threshold survey, the prevalence of HIV-1 drug resistant strain was 5-15. The proportion of Burmese among newly reported HIV-infected individuals aged 16-25 years in Dehong in 2015 was higher. HIV-1 genetic diversity was found in Dehong. The prevalence of HIV-1 drug resistant strain had reached a moderate level in Dehong.

摘要

为研究2015年云南省德宏州未接受抗病毒治疗的HIV感染者中HIV-1耐药传播水平。2015年1月至7月，从德宏州最近报告的16-25岁HIV感染者中收集了72份血浆样本进行耐药基因检测。48份样本成功测序并分析。其中，31.2%（15/48）来自中国人，68.8%（33/48）来自缅甸人。基于序列，HIV基因型包括URF（52.08%，25/48）、CRF01_AE（16.67%，8/48）、RF07_BC（10.42%，5/48）、B亚型（6.25%，3/48）、C亚型（6.25%，3/48）、CRF57_BC（6.25%，3/48）和CRF08_BC（2.08%，1/48）。在4个序列中检测到1个对非核苷类逆转录酶抑制剂（NNRTI）的耐药突变位点和2个对核苷类逆转录酶抑制剂（NRTI）的耐药突变位点。基于HIV耐药阈值调查的统计方法，HIV-1耐药毒株的流行率为5%-15%。2015年德宏州新报告的16-25岁HIV感染者中缅甸人的比例较高。德宏州发现了HIV-1基因多样性。德宏州HIV-1耐药毒株的流行率已达到中等水平。