Zambraski E J, Ciccone C D, Izzo J L
Clin Exp Hypertens A. 1986;8(3):411-24. doi: 10.3109/10641968609039613.
To assess the mechanism responsible for maintaining the elevated arterial pressure in 2-kidney DOCA treated Yucatan miniature swine, cardiovascular parameters and the responses to hexamethonium bromide (HMB) were evaluated in normal and DOCA treated animals. Using chronically instrumented conscious animals, measurements of mean arterial pressure (MAP), cardiac output (CO), and calculated total peripheral resistance (TPR) revealed that with DOCA hypertension MAP was increased 50-60 mmHg above controls. This increased pressure was due to an increase in TPR with CO remaining normal. HMB normalized the MAP of the DOCA animals via a selective lowering of TPR to a value similar to that of the controls. In DOCA hypertensive animals these functional changes, due to increased peripheral sympathetic nerve activity, were reflected by significantly elevated plasma norepinephrine. In this animal DOCA administration produces a neurogenic form of hypertension which appears to be analogous to essential hypertension in man.
为评估在双肾去氧皮质酮（DOCA）处理的尤卡坦小型猪中维持动脉压升高的机制，我们在正常和DOCA处理的动物中评估了心血管参数以及对溴化六甲铵（HMB）的反应。使用长期植入仪器的清醒动物，测量平均动脉压（MAP）、心输出量（CO）和计算得出的总外周阻力（TPR），结果显示，DOCA诱导的高血压使MAP比对照组升高了50 - 60 mmHg。这种血压升高是由于TPR增加而CO保持正常。HMB通过将TPR选择性降低至与对照组相似的值，使DOCA动物的MAP恢复正常。在DOCA高血压动物中，由于外周交感神经活动增加导致的这些功能变化，表现为血浆去甲肾上腺素显著升高。在这种动物中，给予DOCA会产生一种神经源性高血压形式，这似乎与人类的原发性高血压相似。
