Department of Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, 6200MD Maastricht, The Netherlands.
Translational Research Institute for Metabolism and Diabetes, Orlando, FL, USA.
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Oct;1862(10 Pt B):1242-1249. doi: 10.1016/j.bbalip.2017.07.010. Epub 2017 Jul 22.
Skeletal muscle can store excess fat as subcellular lipid droplets (LDs). While originally viewed as uninteresting static balls of triacylglycerol, it is now clear that myocellular LDs play an active role in myocellular (patho)physiology. In this review we aim to discuss the role of LDs in muscle cell insulin sensitivity and identify parameters which appear to affect this relationship. Moreover, we discuss the application of novel tools permitting detailed examination of these parameters. This article is part of a Special Issue entitled: Recent Advances in Lipid Droplet Biology edited by Rosalind Coleman and Matthijs Hesselink.
骨骼肌可以将多余的脂肪储存为细胞内的脂滴（LDs）。虽然最初被视为无趣的三酰基甘油静态球，但现在很清楚，肌细胞 LDs 在肌细胞（病理）生理学中发挥着积极的作用。在这篇综述中，我们旨在讨论 LDs 在肌肉细胞胰岛素敏感性中的作用，并确定似乎影响这种关系的参数。此外，我们还讨论了应用新型工具来详细检查这些参数。本文是由 Rosalind Coleman 和 Matthijs Hesselink 编辑的题为“脂滴生物学新进展”特刊的一部分。
