Marie Aurore, Larroze-Chicot Philippe, Cosnier-Pucheu Sylvie, Gonzalez-Gonzalez Sergio
CILcare. 2214, Boulevard de la Lironde, Parc Scientifique Agropolis, 34397, Montpellier, France.
CILcare. 2214, Boulevard de la Lironde, Parc Scientifique Agropolis, 34397, Montpellier, France.
Neurosci Lett. 2017 Aug 24;656:138-143. doi: 10.1016/j.neulet.2017.07.037. Epub 2017 Jul 21.
Hearing loss is the most common form of sensory impairment in humans, affecting 5.3% worldwide population. In industrial countries, age-related hearing loss is a major health problem affecting one-third of individuals over 65years old. However, the physiological and molecular changes involved in this senescence process remain unclear. In this study, we determined the influence of age on auditory brainstem response (ABR) and the distortion product otoacoustic emissions (DPOAE) in the premature senescence mouse model SAMP8 for five months. We showed a progressive increase of ABR thresholds and a decrease of distortion product amplitude from 37days old in SAMP8 compared to CBA mice. The data we show here provide new knowledge in functional auditory changes during the senescence process and open up new opportunities for the development of new drugs involved in age-related hearing loss treatment.
听力损失是人类最常见的感觉障碍形式，影响着全球5.3%的人口。在工业化国家，年龄相关性听力损失是一个重大的健康问题，影响着三分之一的65岁以上个体。然而，这个衰老过程中涉及的生理和分子变化仍不清楚。在本研究中，我们在早衰小鼠模型SAMP8中持续五个月测定了年龄对听觉脑干反应（ABR）和畸变产物耳声发射（DPOAE）的影响。我们发现，与CBA小鼠相比，SAMP8小鼠从37日龄起ABR阈值逐渐升高，畸变产物幅度降低。我们在此展示的数据为衰老过程中的功能性听觉变化提供了新知识，并为开发与年龄相关性听力损失治疗相关的新药开辟了新机会。
