Schierbeck Juliane, Davidsen Jesper Rømhild, Grindsted Nielsen Sanne, Bille Camilla
Department of Plastic Surgery, Odense University Hospital, Odense, Denmark.
Respiratory Department, Odense University Hospital, Odense, Denmark.
BMJ Case Rep. 2017 Jul 24;2017:bcr-2016-218709. doi: 10.1136/bcr-2016-218709.
Since the 1960s, silicone implants have been used for breast augmentations, both cosmetically and in reconstructive surgery. Tissue exposed to silicone can react with multiple adverse advents. Autoimmune/inflammatory syndrome induced by adjuvants due to silicone exposure from ruptured silicone implants can lead to different interstitial lung manifestations predominantly with granuloma evolvement, leading to the so-called silicone implant incompatibility syndrome (SIIS). This case describes a 57-year-old woman with multiple lung infiltrations and a left-sided breast implant. The implant had been replaced twice, once due to implant rupture 36 years ago. The nodular infiltrates could not be related to infection, malignancy, interstitial lung disease, vasculitis or connective tissue disorder, and it was concluded that the nodular infiltrations were of inflammatory origin due to an autoimmune response secondary to the silicone implants (SIIS). After explantation, the patient's symptoms subsided and her physical condition has remarkably improved.
自20世纪60年代以来，硅胶植入物已被用于隆胸，包括美容隆胸和重建手术。接触硅胶的组织会出现多种不良情况。因硅胶植入物破裂而接触硅胶引发的佐剂诱导的自身免疫/炎症综合征可导致不同的间质性肺表现，主要伴有肉芽肿演变，从而导致所谓的硅胶植入物不相容综合征（SIIS）。本病例描述了一名57岁女性，有多处肺部浸润，左侧有乳房植入物。该植入物已更换过两次，一次是36年前因植入物破裂。结节性浸润与感染、恶性肿瘤、间质性肺疾病、血管炎或结缔组织疾病无关，得出的结论是，结节性浸润是由硅胶植入物继发的自身免疫反应引起的炎症性病变（SIIS）。取出植入物后，患者症状消退，身体状况明显改善。
