The Zabludowicz Center for Autoimmune Diseases, Department of Medicine B' Sheba Medical Center, Tel-Hashomer, Israel.
J Autoimmun. 2011 Feb;36(1):4-8. doi: 10.1016/j.jaut.2010.07.003. Epub 2010 Aug 13.
The role of various environmental factors in the pathogenesis of immune mediated diseases is well established. Of which, factors entailing an immune adjuvant activity such as infectious agents, silicone, aluminium salts and others were associated with defined and non-defined immune mediated diseases both in animal models and in humans. In recent years, four conditions: siliconosis, the Gulf war syndrome (GWS), the macrophagic myofasciitis syndrome (MMF) and post-vaccination phenomena were linked with previous exposure to an adjuvant. Furthermore, these four diseases share a similar complex of signs and symptoms which further support a common denominator.Thus, we review herein the current data regarding the role of adjuvants in the pathogenesis of immune mediated diseases as well as the amassed data regarding each of these four conditions. Relating to the current knowledge we would like to suggest to include these comparable conditions under a common syndrome entitled ASIA, "Autoimmune (Auto-inflammatory) Syndrome Induced by Adjuvants".
各种环境因素在免疫介导性疾病发病机制中的作用已得到充分证实。其中，具有免疫佐剂活性的因素，如感染因子、硅酮、铝盐等，在动物模型和人类中均与明确和非明确的免疫介导性疾病相关。近年来，有四种疾病与先前接触佐剂有关：硅肺、海湾战争综合征（GWS）、巨噬细胞肌筋膜综合征（MMF）和疫苗接种后现象。此外，这四种疾病具有相似的复杂症状和体征，进一步支持存在共同的发病基础。因此，我们在此综述了佐剂在免疫介导性疾病发病机制中的作用以及关于这四种疾病的相关数据。根据目前的知识，我们建议将这些可比的疾病归入一个共同的综合征下，称为 ASIA，即“佐剂诱导的自身免疫（炎症）综合征”。
