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食物过敏的关键问题:美国国家科学院共识研究报告

Critical Issues in Food Allergy: A National Academies Consensus Report.

机构信息

Division of Pediatric Allergy and Immunology, Department of Pediatrics, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, New York;

Centre for Food and Allergy Research, Murdoch Children's Research Institute, The University of Melbourne, Victoria, Australia.

出版信息

Pediatrics. 2017 Aug;140(2). doi: 10.1542/peds.2017-0194.

Abstract

The National Academies of Sciences, Engineering, and Medicine convened an expert, ad hoc committee to examine critical issues related to food allergy. The authors of the resulting report, "Finding a Path to Safety in Food Allergy: Assessment of the Global Burden, Causes, Prevention, Management, and Public Policy," evaluated the scientific evidence on the prevalence, diagnosis, prevention, and management of food allergy and made recommendations to bring about a safe environment for those affected. The committee recommended approaches to monitor prevalence, explore risk factors, improve diagnosis, and provide evidence-based health care. Regarding diagnostics, emphasis was placed on utilizing allergy tests judiciously in the context of the medical history because positive test results are not, in isolation, diagnostic. Evidence-based prevention strategies were advised (for example, a strategy to prevent peanut allergy through early dietary introduction). The report encourages improved education of stakeholders for recognizing and managing as well as preventing allergic reactions, including an emphasis on using intramuscular epinephrine promptly to treat anaphylaxis. The report recommends improved food allergen labeling and evaluation of the need for epinephrine autoinjectors with a dosage appropriate for infants. The committee recommended policies and guidelines to prevent and treat food allergic reactions in a various settings and suggested research priorities to address key questions about diagnostics, mechanisms, risk determinants, and management. Identifying safe and effective therapies is the ultimate goal. This article summarizes the key findings from the report and emphasizes recommendations for actions that are applicable to pediatricians and to the American Academy of Pediatrics.

摘要

美国国家科学院、工程院和医学研究院召集了一个专门的专家委员会,以研究与食物过敏相关的关键问题。该委员会撰写了一份报告,题为《寻找食物过敏安全之路:评估全球负担、病因、预防、管理和公共政策》,评估了关于食物过敏的流行率、诊断、预防和管理的科学证据,并提出了建议,以确保受影响人群的安全环境。委员会建议采取方法来监测流行率、探索风险因素、改进诊断,并提供基于证据的医疗保健。在诊断方面,强调在医学史的背景下明智地使用过敏测试,因为阳性测试结果本身并不能作为诊断依据。建议采用基于证据的预防策略(例如,通过早期饮食引入来预防花生过敏的策略)。该报告鼓励提高利益相关者对识别、管理和预防过敏反应的认识,包括强调及时使用肌肉内肾上腺素来治疗过敏反应。报告建议改进食物过敏原标签,并评估是否需要为婴儿提供适当剂量的肾上腺素自动注射器。委员会建议制定政策和指南,以预防和治疗各种环境中的食物过敏反应,并提出研究优先事项,以解决关于诊断、机制、风险决定因素和管理的关键问题。确定安全有效的治疗方法是最终目标。本文总结了报告的主要发现,并强调了适用于儿科医生和美国儿科学会的行动建议。

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Prospects for Prevention of Food Allergy.食物过敏的预防前景
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Anaphylaxis--a practice parameter update 2015.过敏反应——2015年实践参数更新
Ann Allergy Asthma Immunol. 2015 Nov;115(5):341-84. doi: 10.1016/j.anai.2015.07.019.
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Nutritional aspects and diets in food allergy.食物过敏中的营养因素与饮食
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