Vandongen R, Margetts B, Beilin L J, deKlerk N, Rogers P
Eur J Clin Pharmacol. 1986;30(3):283-7. doi: 10.1007/BF00541529.
This study examines and compares the hemodynamic and sympathoadrenal response to bicycle exercise in hypertensive subjects during two weeks' treatment with a cardio-selective (metoprolol) and nonselective (propranolol) beta-blocker. The increase in plasma norepinephrine and epinephrine concentration following exercise was augmented to a similar degree with each beta-blocker. Pre-exercise blood pressure and heart rate were similar for the two drugs. However immediately after exercise and particularly after resting for 20 min post exercise, diastolic blood pressure was lower during metoprolol treatment. Systolic blood pressure was also lower 20 min post exercise during metoprolol treatment. These observations indicate that cardio-selective beta-blockers offer advantages in blood pressure control during exercise through intact vascular beta 2-adrenoceptors opposing sympathetically mediated vasoconstriction.
本研究检测并比较了高血压患者在使用心脏选择性（美托洛尔）和非选择性（普萘洛尔）β受体阻滞剂进行两周治疗期间，自行车运动时的血流动力学及交感肾上腺反应。运动后血浆去甲肾上腺素和肾上腺素浓度的升高在每种β受体阻滞剂作用下均有相似程度的增强。两种药物治疗前的血压和心率相似。然而，运动后即刻，尤其是运动后休息20分钟后，美托洛尔治疗期间的舒张压较低。美托洛尔治疗期间运动后20分钟收缩压也较低。这些观察结果表明，心脏选择性β受体阻滞剂通过完整的血管β2肾上腺素能受体对抗交感神经介导的血管收缩，在运动期间的血压控制方面具有优势。
