Triki Mouna, Lapierre Marion, Cavailles Vincent, Mokdad-Gargouri Raja
Mouna Triki, Marion Lapierre, Vincent Cavailles, IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier, 34298 Montpellier, France.
World J Gastroenterol. 2017 Jul 7;23(25):4480-4490. doi: 10.3748/wjg.v23.i25.4480.
Colorectal cancer (CRC) is one of the most common human cancers and the cause of about 700000 deaths per year worldwide. Deregulation of the WNT/β-catenin pathway is a key event in CRC initiation. This pathway interacts with other nuclear signaling pathways, including members of the nuclear receptor superfamily and their transcription coregulators. In this review, we provide an overview of the literature dealing with the main coactivators (NCoA-1 to 3, NCoA-6, PGC1-α, p300, CREBBP and MED1) and corepressors (N-CoR1 and 2, NRIP1 and MTA1) of nuclear receptors and summarize their links with the WNT/β-catenin signaling cascade, their expression in CRC and their role in intestinal physiopathology.
结直肠癌（CRC）是最常见的人类癌症之一，也是全球每年约70万人死亡的原因。WNT/β-连环蛋白信号通路失调是结直肠癌发生的关键事件。该信号通路与其他核信号通路相互作用，包括核受体超家族成员及其转录共调节因子。在本综述中，我们概述了有关核受体主要共激活因子（NCoA-1至3、NCoA-6、PGC1-α、p300、CREBBP和MED1）和共抑制因子（N-CoR1和2、NRIP1和MTA1）的文献，并总结了它们与WNT/β-连环蛋白信号级联的联系、它们在结直肠癌中的表达及其在肠道生理病理学中的作用。
