视黄酸抑制解离的穆勒胶质细胞向晶状体样细胞的转化。

Retinoic acid inhibits conversion of dissociated Müller glia into lens-like cells.

作者信息

Degenstein L, Moscona A A

出版信息

Exp Eye Res. 1986 Jul;43(1):93-102. doi: 10.1016/s0014-4835(86)80048-3.

Abstract

In monolayer cultures of dissociated retina cells, Müller gliocytes undergo conversion into a lens-like cell type (lentoidal cells): they become unable to adhere to neurons and accumulate lens antigens. Retinoic acid (RA) retards these changes. We present evidence that RA prevents the rapid loss of gliocyte adhesivity to neurons; and that, by promoting restoration of glia cell contacts with neurons, RA protects the gliocytes from phenotype alteration.

摘要

在解离的视网膜细胞单层培养物中， Müller胶质细胞会转化为一种晶状体样细胞类型（类晶状体细胞）：它们变得无法黏附于神经元，并积累晶状体抗原。视黄酸（RA）可延缓这些变化。我们提供的证据表明，RA可防止胶质细胞与神经元之间的黏附性迅速丧失；并且，通过促进胶质细胞与神经元恢复接触，RA可保护胶质细胞不发生表型改变。