Ren Gai-Xian, Guo Xiao-Peng, Sun Yi-Cheng
MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing, China.
Front Microbiol. 2017 Jul 10;8:1276. doi: 10.3389/fmicb.2017.01276. eCollection 2017.
The untranslated regions (UTRs) of mRNA contain important features that are relevant to the post-transcriptional and translational regulation of gene expression. Most studies of bacterial UTRs have focused on the 5'regions; however, 3'UTRs have recently emerged as a new class of post-transcriptional regulatory elements. 3'UTRs were found to regulate the decay and translation initiation in their own mRNAs. In addition, 3'UTRs constitute a rich reservoir of small regulatory RNAs, regulating target gene expression. In the current review, we describe several recently discovered examples of bacterial regulatory 3'UTRs, discuss their modes of action, and illustrate how they facilitate gene regulation in various environments.
信使核糖核酸（mRNA）的非翻译区（UTR）含有与基因表达的转录后和翻译调控相关的重要特征。大多数关于细菌UTR的研究都集中在5'区域；然而，3'UTR最近已成为一类新的转录后调控元件。研究发现3'UTR可调节自身mRNA的降解和翻译起始。此外，3'UTR构成了一个丰富的小调控RNA库，可调节靶基因的表达。在本综述中，我们描述了几个最近发现的细菌调控3'UTR的例子，讨论了它们的作用模式，并说明了它们如何在各种环境中促进基因调控。
