Nieder Carsten, Langendijk Johannes A, Guckenberger Matthias, Grosu Anca L
Department of Oncology and Palliative Medicine, Nordland Hospital Trust, Bodø, Norway.
Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.
Adv Radiat Oncol. 2017 Feb 28;2(2):176-182. doi: 10.1016/j.adro.2017.02.005. eCollection 2017 Apr-Jun.
The purpose of this study is to illustrate the historical development of reirradiation during several decades of the 20th century, in particular between 1920 and 1960.
We chose the format of a narrative review because the historical articles are heterogeneous. No systematic extraction of baseline data, treatment details, or follow-up care was possible in many cases.
Both hematological malignancies and solid tumors were treated with a second course of radiation therapy, and indications included local relapse, regional nodal recurrence, and second primary tumors developing in a previously treated region. The literature consists of retrospective single-institution analyses describing treatment approaches that included external beam radiation therapy, brachytherapy, or combinations thereof. Data on toxicities and survival were often provided. Breast cancer and gynecological, head and neck, brain, and skin tumors are among the entities included in this review.
The leading pioneers in the field are fully aware of many of the challenges we continue to debate today. These include the process of late tissue changes and development of personalized treatment approaches and better ways to select patients who are likely to benefit from a second course of radiation therapy.
本研究旨在阐述20世纪几十年间，尤其是1920年至1960年间再程放疗的历史发展。
我们选择叙述性综述的形式，因为历史文献具有异质性。在许多情况下，无法对基线数据、治疗细节或后续护理进行系统提取。
血液系统恶性肿瘤和实体瘤均接受了第二疗程的放射治疗，适应症包括局部复发、区域淋巴结复发以及在先前治疗区域出现的第二原发肿瘤。文献包括回顾性单机构分析，描述了包括外照射放疗、近距离放疗或两者联合的治疗方法。通常会提供毒性和生存数据。本综述涵盖的实体瘤包括乳腺癌、妇科肿瘤、头颈部肿瘤、脑肿瘤和皮肤肿瘤。
该领域的主要先驱者充分意识到我们如今仍在争论的许多挑战。这些挑战包括晚期组织变化的过程、个性化治疗方法的发展，以及更好地选择可能从第二疗程放射治疗中获益的患者的方法。
