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腋股旁路移植术:通过分析结果和预后因素对一种非解剖旁路移植术的再评估。

Axillobifemoral Bypasses: Reappraisal of an Extra-Anatomic Bypass by Analysis of Results and Prognostic Factors.

机构信息

Department for General, Vascular, and Thoracic Surgery, University of Bonn Medical School, Sigmund-Freud-Straße 25, 53127, Bonn, Germany.

出版信息

World J Surg. 2018 Jan;42(1):283-294. doi: 10.1007/s00268-017-4150-0.

Abstract

BACKGROUND

Axillobifemoral bypass (AFB) is method of second choice. It is reserved for patients at high operative risk or to bypass infected vessels or grafts. In this study, we analyzed prognostic factors for AFB patency and limb salvage rate to facilitate the choice of procedure.

METHODS

Between Jan 2006 and Aug 2013, 45 patients underwent AFB surgery in our department, 24 for critical limb ischemia (CLI) and 23 for infection. Endpoints of study were graft occlusion, graft infection, amputation and patient's death. Prognostic factors were compared by univariate analysis for each indication group. Mean follow-up was 40.2 (±23.2) months.

RESULTS

Complication rate was significantly higher in infection group (88.0 vs. 54.4%, p = 0.003) and in emergency surgery (83.3 vs. 56.9%, p = 0.023). Overall primary patency rate after AFB procedures was 66.7% after 1, 3, and 5 years, while secondary patency rate was 91.1% after 1 year, 82.2% after 3 years and 80.0% after 5 years. The primary and secondary patency rates did not significantly differ between the both groups (p = 0.059 and p = 0.136). Following prognostic factors showed a statistically significant influence on patency rates in CLI group: >1 previous vascular surgical intervention, patch angioplasty at the distal anastomosis site, complications after previous vascular surgery, and perioperative intake of platelet aggregation inhibitor. Only the employed bypass material had a statistical significant influence on the secondary patency rates in the infection group. Overall limb salvage rate was 82.2% after 1 year, 80.0% after 3 years and 77.8% after 5 years. There were statistically significant differences in the limb salvage rates depending on emergency surgery and a 3-vessel-run-off in the lower leg in both indication groups.

CONCLUSION

AFB have acceptable patency and limb salvage rates. AFB is a good alternative in patients with CLI at high operative risk or with infections of aortoiliac segments, even with endovascular approaches. They remain essential tools in vascular surgeon's repertoire.

摘要

背景

腋股旁路移植术(AFB)是二线治疗方法。它适用于手术风险高的患者,或用于旁路感染的血管或移植物。本研究旨在分析影响 AFB 通畅率和保肢率的预后因素,以便选择手术方式。

方法

2006 年 1 月至 2013 年 8 月,我院 45 例患者接受 AFB 手术,其中 24 例为严重肢体缺血(CLI),23 例为感染。研究终点为移植物闭塞、移植物感染、截肢和患者死亡。对每个适应证组进行单因素分析比较预后因素。平均随访时间为 40.2(±23.2)个月。

结果

感染组并发症发生率显著高于 CLI 组(88.0%比 54.4%,p=0.003)和急诊手术组(83.3%比 56.9%,p=0.023)。AFB 手术后 1、3、5 年的总通畅率分别为 66.7%、60.0%和 53.3%,而 1 年、3 年和 5 年的二次通畅率分别为 91.1%、82.2%和 80.0%。两组间的总通畅率和二次通畅率无显著差异(p=0.059 和 p=0.136)。CLI 组中,以下预后因素对通畅率有统计学显著影响:>1 次血管外科干预、远端吻合口处补片血管成形术、既往血管外科手术后并发症、围手术期血小板聚集抑制剂的应用。只有感染组的旁路移植材料对二次通畅率有统计学显著影响。1 年、3 年和 5 年的总保肢率分别为 82.2%、80.0%和 77.8%。两组中,急诊手术和小腿 3 支血管通畅均与保肢率显著相关。

结论

AFB 具有可接受的通畅率和保肢率。对于 CLI 高危患者或合并主髂段感染的患者,即使采用血管内治疗,AFB 也是一种较好的选择。它们仍然是血管外科医生技术手段的重要组成部分。

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