基因冗余、功能补偿与癌症易感性

Genetic Redundancy, Functional Compensation, and Cancer Vulnerability.

作者信息

Cereda Matteo, Mourikis Thanos P, Ciccarelli Francesca D

机构信息

Division of Cancer Studies, King's College London, London SE1 1UL, UK.

出版信息

Trends Cancer. 2016 Apr;2(4):160-162. doi: 10.1016/j.trecan.2016.03.003. Epub 2016 Mar 28.

DOI:10.1016/j.trecan.2016.03.003

PMID:28741568

Abstract

Cancer genomes acquire somatic alterations that largely differ between and within cancer types. Several of these alterations inactivate genes that are normally functional with no deleterious consequences on cancer cells due to genetic redundancy. Here we discuss how this leads to cancer synthetic dependencies that can be exploited in therapy.

摘要

癌症基因组会发生体细胞改变，这些改变在不同癌症类型之间以及同一癌症类型内部都有很大差异。其中一些改变会使那些在正常情况下具有功能的基因失活，但由于基因冗余，这些基因失活对癌细胞并无有害影响。在此，我们讨论这种情况如何导致癌症合成依赖性，而这种依赖性可在治疗中加以利用。