Fallon J H, Leslie F M
J Comp Neurol. 1986 Jul 15;249(3):293-336. doi: 10.1002/cne.902490302.
The neuroanatomical distribution of dynorphin B-like immunoreactivity (DYN-B) was studied in the adult male and female albino rat. The distribution of DYN B in colchicine- and noncolchicine-treated animals was also compared to that of another opioid peptide derived from the prodynorphin precursor dynorphin A (1-8) (DYN 1-8), and an opioid peptide derived from the proenkephalin precursor met-enkephalin-arg-gly-leu (MERGL). DYN B cell bodies were present in nonpyramidal cells of neo- and allocortices, medium-sized cells of the caudate-putamen, nucleus accumbens, lateral part of the central nucleus of the amygdala, bed nucleus of the stria terminalis, preoptic area, and in sectors of nearly every hypothalamic nucleus and area, medial pretectal area, and nucleus of the optic tract, periaqueductal gray, raphe nuclei, cuneiform nucleus, sagulum, retrorubral nucleus, peripeduncular nucleus, lateral terminal nucleus, pedunculopontine nucleus, mesencephalic trigeminal nucleus, parabigeminal nucleus, dorsal nucleus of the lateral lemniscus, lateral superior olivary nucleus, superior paraolivary nucleus, medial superior olivary nucleus, ventral nucleus of the trapezoid body, lateral dorsal tegmental nucleus, accessory trigeminal nucleus, solitary nucleus, nucleus ambiguus, paratrigeminal nucleus, area postrema, lateral reticular nucleus, and ventrolateral region of the reticular formation. Fiber systems are present that conform to many of the known output systems of these nuclei, including major descending pathways (e.g., striatonigral, striatopallidal, reticulospinal, hypothalamospinal pathways), short projection systems (e.g., mossy fibers in hippocampus, hypothalamo-hypophyseal pathways), and local circuit pathways (e.g., in cortex, hypothalamus). The distribution of MERGL was, with a few notable exceptions, in the same nuclei as DYN B. From these neuroanatomical data, it appears that the dynorphin and enkephalin peptides are strategically located in brain regions that regulate extrapyramidal motor function, cardiovascular and water balance systems, eating, sensory processing, and pain perception.
研究了成年雄性和雌性白化大鼠中强啡肽B样免疫反应性（DYN-B）的神经解剖分布。还比较了秋水仙碱处理和未处理动物中DYN B的分布与源自强啡肽原前体强啡肽A（1-8）（DYN 1-8）的另一种阿片肽以及源自脑啡肽原前体甲硫脑啡肽-精氨酸-甘氨酸-亮氨酸（MERGL）的阿片肽的分布。DYN B细胞体存在于新皮质和旧皮质的非锥体细胞、尾状壳核的中型细胞、伏隔核、杏仁核中央核外侧部分、终纹床核、视前区以及几乎每个下丘脑核和区域、内侧顶盖前区、视束核、导水管周围灰质、中缝核、楔形核、穹窿、红核后核、脚周核、外侧终核、脚桥核、中脑三叉神经核、副视束核、外侧丘系背核、外侧上橄榄核、上橄榄旁核、内侧上橄榄核、梯形体腹侧核、外侧背侧被盖核、副三叉神经核、孤束核、疑核、三叉旁核、最后区、外侧网状核以及网状结构的腹外侧区域。存在符合这些核的许多已知输出系统的纤维系统，包括主要的下行通路（如纹状体黑质、纹状体苍白球、网状脊髓、下丘脑脊髓通路）、短投射系统（如海马中的苔藓纤维、下丘脑-垂体通路）和局部回路通路（如在皮质、下丘脑中）。除了一些明显的例外，MERGL的分布与DYN B在相同的核中。从这些神经解剖学数据来看，强啡肽和脑啡肽似乎战略性地位于调节锥体外系运动功能、心血管和水平衡系统、进食、感觉处理和痛觉的脑区。
