Logoĭda D M
Arkh Patol. 1979;41(5):12-8.
Five hundred lymph nodes taken from various parts of the body in 89 patients who had died of acute granulocytic leukemia at the age of 3 to 71 years were examined. The degree of involvement of lymph nodes of the same patient was different and depended of their site: more frequent and pronounced changes were found in submaxillary, cervical, and retroperitoneal lymph nodes, less marked in inguinal and mesenterial nodes. The earliest infiltrates of oxidase-positive cells appeared in hilus fat around small arteries, then in the medullary part and, finally, in the cortex. In sinuses, the oxidase-positive cells accumulated later than in the medullary part, were more mature and sometimes were phagocytized by histocytes. A direct correlation between the degree of myeloid infiltration in the lymph nodes and the number of leukocytes in the peripheral blood was observed. These results and data of the literature suggest a metastatic genesis of myeloid infiltrates.
对89例年龄在3至71岁之间死于急性粒细胞白血病的患者的500个取自身体各个部位的淋巴结进行了检查。同一患者的淋巴结受累程度不同，且取决于其部位：颌下、颈部和腹膜后淋巴结的变化更频繁、更明显，腹股沟和肠系膜淋巴结的变化则不太明显。最早的氧化酶阳性细胞浸润出现在小动脉周围的肺门脂肪中，然后出现在髓质部分，最后出现在皮质。在窦中，氧化酶阳性细胞比在髓质部分积累得晚，更成熟，有时会被组织细胞吞噬。观察到淋巴结中髓样浸润程度与外周血白细胞数量之间存在直接相关性。这些结果和文献数据提示髓样浸润的转移起源。
