血清铁蛋白作为显微镜下多血管炎的活性标志物。
Serum ferritin as an activity marker for granulamotosis with polyangiitis.
作者信息
Kucuk Hamit, Varan Ozkan, Goker Berna, Bitik Berivan, Ozturk Mehmet Akif, Haznedaroglu Seminur, Tufan Abdurrahman
机构信息
a Department of Internal Medicine, Division of Rheumatology, Faculty of Medicine , Gazi University , Ankara , Turkey.
出版信息
Ren Fail. 2017 Nov;39(1):566-569. doi: 10.1080/0886022X.2017.1349675.
BACKGROUND
Serum ferritin correlates well with the activities of systemic lupus erythematosus (SLE) and dermatomyositis, but it has not been previously studied in patients with vasculitis.
METHODS
Medical records of granulomatosis with polyangiitis (GPA, Wegener's granulomatosis) patients with at least six months of regular follow-up were evaluated. The activity of GPA was assessed with Birmingham Vasculitis Activity Score for Wegener's Granulomatosis (BVAS/WG). Serum ferritin and other acute phase markers were measured at initial presentation.
RESULTS
Serum ferritin levels were found to be the highest in GPA patients with alveolar hemorrhage, median (IQR) 1041 (1281) μg/L. Patients with renal disease also had high levels of ferritin and it was correlated with concurrent glomerular filtration rate (r = -0.65, p < .001). Serum ferritin is also correlated well with the BVAS/WG scores (r = 0.79, p < .001).
CONCLUSIONS
Measurement of serum ferritin might help in assessing disease activity of GPA.
背景
血清铁蛋白与系统性红斑狼疮（SLE）和皮肌炎的活动情况密切相关，但此前尚未在血管炎患者中进行研究。
方法
对患有肉芽肿性多血管炎（GPA，韦格纳肉芽肿）且有至少六个月定期随访的患者的病历进行评估。采用韦格纳肉芽肿伯明翰血管炎活动评分（BVAS/WG）评估GPA的活动情况。在初次就诊时测量血清铁蛋白和其他急性期标志物。
结果
发现肺泡出血的GPA患者血清铁蛋白水平最高，中位数（四分位间距）为1041（1281）μg/L。患有肾脏疾病的患者铁蛋白水平也较高，且与同时期的肾小球滤过率相关（r = -0.65，p <.001）。血清铁蛋白也与BVAS/WG评分密切相关（r = 0.79，p <.001）。
结论
测量血清铁蛋白可能有助于评估GPA的疾病活动情况。
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